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    MSS1 Mss1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855037, updated on 17-May-2024

    Summary

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    Gene symbol
    MSS1
    Gene description
    Mss1p
    Primary source
    FungiDB:YMR023C
    Locus tag
    YMR023C
    See related
    SGD:S000004625; AllianceGenome:SGD:S000004625; VEuPathDB:YMR023C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PET53
    Summary
    Predicted to enable GTP binding activity. Involved in mitochondrial tRNA wobble uridine modification. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MSS1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (319437..321017, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mac1p Neighboring gene E2 ubiquitin-conjugating protein UBC7 Neighboring gene tRNA-Ala Neighboring gene mitochondrial 54S ribosomal protein YmL3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. Decoster E, et al. J Mol Biol, 1993 Jul 5. PMID 8392589
    2. MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. Colby G, et al. J Biol Chem, 1998 Oct 23. PMID 9774408
    3. A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation. Li X, et al. Mol Cell Biol, 2002 Nov. PMID 12370316, Free PMC Article
    4. Peripheral mitochondrial inner membrane protein, Mss2p, required for export of the mitochondrially coded Cox2p C tail in Saccharomyces cerevisiae. Broadley SA, et al. Mol Cell Biol, 2001 Nov. PMID 11604502, Free PMC Article
    5. Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae. Garcia-Ranea JA, et al. FEBS Lett, 1998 Sep 4. PMID 9742927

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mss1 mutation led to a significant increase in the steady-state level of HAP5 (heme activated protein), which greatly up-regulated the expression of glycolytic transcription factors RAP1, GCR1, and GCR2 and thus stimulated glycolysis
      Title: Mechanistic study on the nuclear modifier gene MSS1 mutation suppressing neomycin sensitivity of the mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiae.
    2. These results support the hypothesis that Mss116p and Pet127p are involved in modulation of mtRNAP activity.
      Title: Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification.
    3. Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assemb
      Title: Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mss1p
    NP_013736.1
    • Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      319437..321017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182519.1 → NP_013736.1  TPA: Mss1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013736.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZJ7, P32559, Q0PHA7
      UniProtKB/TrEMBL
      A0A8H4BYM5, A6ZM85, B3LLS4, C7GL96, C8ZEN0, N1NY71
      Conserved Domains (1) summary
      COG0486
      Location:38 → 526
      MnmE; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32559.2

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