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    FRE7 putative ferric-chelate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854013, updated on 17-May-2024

    Summary

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    Gene symbol
    FRE7
    Gene description
    putative ferric-chelate reductase
    Primary source
    FungiDB:YOL152W
    Locus tag
    YOL152W
    See related
    SGD:S000005512; AllianceGenome:SGD:S000005512; VEuPathDB:YOL152W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ferric-chelate reductase activity. Involved in copper ion import and iron ion transport. Located in plasma membrane. Orthologous to several human genes including NOX1 (NADPH oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FRE7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (40748..42610)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Zps1p Neighboring gene pseudo Neighboring gene methylglyoxal reductase (NADPH-dependent) GRE2 Neighboring gene Dcp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption and phenotypic analysis of seven ORFs from the left arm of chromosome XV of Saccharomyces cerevisiae. Hajji K, et al. Yeast, 1999 Mar 30. PMID 10220002
    2. DNA sequence analysis of a 13 kbp fragment of the left arm of yeast chromosome XV containing seven new open reading frames. Casamayor A, et al. Yeast, 1995 Oct. PMID 8553699
    3. The metalloreductase Fre6p in Fe-efflux from the yeast vacuole. Singh A, et al. J Biol Chem, 2007 Sep 28. PMID 17681937
    4. The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae. Casas C, et al. Yeast, 1997 Jun 15. PMID 9200812
    5. Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization. Rees EM, et al. J Biol Chem, 2007 Jul 27. PMID 17553781

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferric-chelate reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric-chelate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferric-chelate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide-generating NAD(P)H oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion import IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in copper ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reductive iron assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ferric-chelate reductase
    NP_014489.2
    • Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      40748..42610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183406.1 → NP_014489.2  TPA: putative ferric-chelate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014489.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1R8, Q12333
      UniProtKB/TrEMBL
      A0A8H4BUP2, C7GQ31, N1P2S4
      Conserved Domains (3) summary
      cd06186
      Location:328 → 500
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam08030
      Location:423 → 596
      NAD_binding_6; Ferric reductase NAD binding domain
      pfam01794
      Location:164 → 278
      Ferric_reduct; Ferric reductase like transmembrane component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12333.2

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