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    TDA4 Tda4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853580, updated on 13-Apr-2024

    Summary

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    Gene symbol
    TDA4
    Gene description
    Tda4p
    Primary source
    SGD:S000003877
    Locus tag
    YJR116W
    See related
    AllianceGenome:SGD:S000003877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in lipid homeostasis. Located in endoplasmic reticulum. Orthologous to several human genes including TLCD4 (TLC domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (640825..641664)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein RSM7 Neighboring gene uncharacterized protein Neighboring gene zinc metalloprotease Neighboring gene Ilm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae. Mallela SK, et al. PLoS One, 2016. PMID 26752183, Free PMC Article
    2. Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Reid RJ, et al. Genome Res, 2011 Mar. PMID 21173034, Free PMC Article
    3. Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions. León Ortiz AM, et al. DNA Repair (Amst), 2011 May 5. PMID 21459050, Free PMC Article
    4. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article
    5. A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Finnigan GC, et al. Genetics, 2011 Mar. PMID 21196517, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both yjr116w and ypr114w deleted mutants have fragmented vacuoles and produce less reactive oxygen species than wild type.
      Title: Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tda4p
    NP_012650.1
    • Protein distantly similar to ceramide synthases, Lag1p and Lac1p; null mutant is sensitive to expression of the top1-T722A allele; mutation confers sensitivity to copper

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      640825..641664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181774.1 → NP_012650.1  TPA: Tda4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012650.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWT5, P47153
      UniProtKB/TrEMBL
      A0A6A5PUZ6, A6ZQ72, B3LQK0, C7GM95, C8ZBR4, G2WHB9, N1P1R4
      Conserved Domains (1) summary
      smart00724
      Location:72 → 271
      TLC; TRAM, LAG1 and CLN8 homology domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47153.1

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