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    NMD5 Nmd5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853596, updated on 17-May-2024

    Summary

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    Gene symbol
    NMD5
    Gene description
    Nmd5p
    Primary source
    FungiDB:YJR132W
    Locus tag
    YJR132W
    See related
    SGD:S000003893; AllianceGenome:SGD:S000003893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAP119
    Summary
    Enables nuclear import signal receptor activity. Involved in protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO7 (importin 7) and IPO8 (importin 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NMD5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (669522..672668)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene cystathionine gamma-synthase Neighboring gene mannosyl-oligosaccharide 1,2-alpha-mannosidase Neighboring gene xanthine phosphoribosyltransferase Neighboring gene Sgm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulated nuclear accumulation of the yeast hsp70 Ssa4p in ethanol-stressed cells is mediated by the N-terminal domain, requires the nuclear carrier Nmd5p and protein kinase C. Quan X, et al. FASEB J, 2004 May. PMID 15001563
    2. Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p. Polizotto RS, et al. J Cell Biol, 2001 Sep 3. PMID 11535618, Free PMC Article
    3. Starvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells. Chughtai ZS, et al. J Biol Chem, 2001 Jun 8. PMID 11279056
    4. Dissecting the roles of Cse1 and Nup2 in classical NLS-cargo release in vivo. Lange A, et al. Traffic, 2020 Oct. PMID 32734712, Free PMC Article
    5. Structural basis for nuclear import complex dissociation by RanGTP. Lee SJ, et al. Nature, 2005 Jun 2. PMID 15864302

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear periphery HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nmd5p
    NP_012666.2
    • Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      669522..672668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181790.2 → NP_012666.2  TPA: Nmd5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012666.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWV0, P46970
      UniProtKB/TrEMBL
      A0A8H4BZX7, B3LQL4
      Conserved Domains (1) summary
      COG5656
      Location:2 → 1048
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46970.2

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