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    MFA1 mating pheromone a [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852072, updated on 17-May-2024

    Summary

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    Gene symbol
    MFA1
    Gene description
    mating pheromone a
    Primary source
    FungiDB:YDR461W
    Locus tag
    YDR461W
    See related
    SGD:S000002869; AllianceGenome:SGD:S000002869; VEuPathDB:YDR461W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mating pheromone activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MFA1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1385176..1385286)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene palmitoyltransferase PFA5 Neighboring gene TFIIH/NER complex subunit TFB3 Neighboring gene Cmi8p Neighboring gene mitochondrial 54S ribosomal protein YmL28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An amino terminal prosequence is required for efficient synthesis of S. cerevisiae a-factor. Quinby GE, et al. Biochim Biophys Acta, 1997 Mar 27. PMID 9099988
    2. Synthesis and farnesylation of a-factor fusion proteins in Saccharomyces cerevisiae. Kölling R, et al. FEBS Lett, 1993 Dec 20. PMID 8262194
    3. Specificity characterization of the α-mating factor hormone by Kex2 protease. Manfredi MA, et al. Biochimie, 2016 Dec. PMID 27720750
    4. Facile synthesis of budding yeast a-factor and its use to synchronize cells of α mating type. O'Reilly N, et al. Yeast, 2012 Jun. PMID 22641466
    5. Structure, biological activity and membrane partitioning of analogs of the isoprenylated a-factor mating peptide of Saccharomyces cerevisiae. Xie H, et al. J Pept Res, 2000 May. PMID 10863934

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate the substrate specificity of kexin protein(Kex2)using peptides derived from alpha-mating factor.
      Title: Specificity characterization of the α-mating factor hormone by Kex2 protease.
    2. The loss of viability observed in telomerase-deficient haploids and diploids is less severe when both MATa and MATalpha are co-expressed than when a single MAT allele is expressed.
      Title: Mating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion.
    3. Amino acid residues critical for N-terminal processing, protein secretion, and mating were identified from a collection of a-factor mutants.
      Title: Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mating pheromone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mating pheromone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pheromone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mating pheromone a
    NP_010749.3
    • Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1385176..1385286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180769.3 → NP_010749.3  TPA: mating pheromone a [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010749.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT85, P34165
      UniProtKB/TrEMBL
      A0A8H8UNZ4, A6ZZ51, B3LFK4, C7GKQ2, C8Z619, G2WBJ1, N1P5P2
      Conserved Domains (1) summary
      pfam17317
      Location:1 → 36
      MFA1_2; Mating hormone A-factor 1_2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34165.1

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