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    CDR1 cerebellar degeneration related 1 [ Homo sapiens (human) ]

    Gene ID: 1038, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CDR1provided by HGNC
    Official Full Name
    cerebellar degeneration related 1provided by HGNC
    Primary source
    HGNC:HGNC:1798
    See related
    MIM:302650; AllianceGenome:HGNC:1798
    Gene type
    unknown
    RefSeq status
    MODEL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDR; CDR34; CDR62A
    Orthologs
    all

    Genomic context

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    Location:
    Xq27.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (140772083..140793212, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (139089454..139110579, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373344 Neighboring gene NANOG hESC enhancer GRCh37_chrX:139608152-139608653 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:139655621-139655814 Neighboring gene uncharacterized LOC101928833 Neighboring gene NANOG hESC enhancer GRCh37_chrX:139805503-139806004 Neighboring gene long intergenic non-protein coding RNA 632 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:139865334-139866831 Neighboring gene microRNA 320d-2 Neighboring gene SPANX family member B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cerebellar Degeneration-related Antigen 1 Is Ubiquitously Expressed in Human Epidermis and Dermis. Wang LL, et al. Curr Med Sci, 2020 Jun. PMID 32681261
    2. Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in Alzheimer's disease. Bosco P, et al. Neurol Sci, 2014 Oct. PMID 24777548
    3. Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in prostate cancer cell lines. Salemi M, et al. Int J Biol Markers, 2014 Sep 30. PMID 24366849
    4. The tolerogenic peptide, hCDR1, down-regulates the expression of interferon-α in murine and human systemic lupus erythematosus. Sthoeger Z, et al. PLoS One, 2013. PMID 23555966, Free PMC Article
    5. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. Dropcho EJ, et al. Proc Natl Acad Sci U S A, 1987 Jul. PMID 3474619, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cerebellar Degeneration-related Antigen 1 Is Ubiquitously Expressed in Human Epidermis and Dermis.
      Title: Cerebellar Degeneration-related Antigen 1 Is Ubiquitously Expressed in Human Epidermis and Dermis.
    2. Our study confirmed that the circ_0001946/miR-671-5p/ CDR1 pathway modulates the development of glioblastoma
      Title: Circular RNA circ_0001946 acts as a competing endogenous RNA to inhibit glioblastoma progression by modulating miR-671-5p and CDR1.
    3. Underexpression of CDR1 is associated with glioblastoma multiforme.
      Title: Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme.
    4. The results of this case-control study showed that the CDR1 gene was over-expressed in five out of seven subjects with AD compared to seven age- and sex-matched normal controls. Data suggest that CDR1 gene may play a role, in Alzheimer's disease process.
      Title: Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in Alzheimer's disease.
    5. The CDR1 gene was overexpressed in the LNCaP and PC-3 PCa cell lines as compared with the PNT1A normal prostate cell line.
      Title: Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in prostate cancer cell lines.
    6. Treatment of systemic lupus erythematosus afflicted (NZBxNZW)F1 mice with human CDR1 down regulated gene expression of IFN-alpha.
      Title: The tolerogenic peptide, hCDR1, down-regulates the expression of interferon-α in murine and human systemic lupus erythematosus.
    7. miR-671 directs cleavage of a circular antisense transcript of the Cerebellar Degeneration-Related protein 1 (CDR1) locus in an Ago2-slicer-dependent manner.
      Title: miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • cerebellar degeneration related protein 1
    • cerebellar degeneration-related antigen 1
    • cerebellar degeneration-related protein 1, 34kDa

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      140772083..140793212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_006652813.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      139089454..139110579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007091041.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_016361.1: Suppressed sequence

      Description
      NG_016361.1: This RefSeq was removed by NCBI staff.

    2. NM_004065.2: Suppressed sequence

      Description
      NM_004065.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51861.2 GenPept UniProtKB/Swiss-Prot:P51861

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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    Tools
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