LGALS7 galectin 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LGALS7provided by HGNC
Official Full Name: galectin 7provided by HGNC
Primary source: HGNC:HGNC:6568
See related: Ensembl:ENSG00000205076 MIM:600615; AllianceGenome:HGNC:6568
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GAL7; LGALS7A
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward skin (RPKM 300.6) See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (38770968..38773517, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (41575026..41577575, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39261608..39264157, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
Title: Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions.
Title: Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions.
Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes.
Title: Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes.
CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury.
Title: CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury.
Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
Title: Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.
Title: Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.
Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.
Title: Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.
Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.
Title: Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.
Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression.
Title: Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression.
Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis.
Title: Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80063 (e-PCR)
- UniSTS:91678

RH66782 (e-PCR)
- UniSTS:55229

General protein information

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Preferred Names: galectin-7

Names: lectin, galactoside-binding, soluble, 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.