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    Zbtb14 zinc finger and BTB domain containing 14 [ Mus musculus (house mouse) ]

    Gene ID: 22666, updated on 2-May-2024

    Summary

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    Official Symbol
    Zbtb14provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 14provided by MGI
    Primary source
    MGI:MGI:1195345
    See related
    Ensembl:ENSMUSG00000049672 AllianceGenome:MGI:1195345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZF5; Zfp161; b2b1982Clo
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within heart development and kidney development. Predicted to be located in aggresome; cytosol; and nucleolus. Predicted to be active in nucleoplasm. Is expressed in ureter. Orthologous to human ZBTB14 (zinc finger and BTB domain containing 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.3), CNS E14 (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.3; 17 40.42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (69690170..69697747)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (69383175..69390752)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 3 Neighboring gene RIKEN cDNA 2410021H03 gene Neighboring gene STARR-seq mESC enhancer starr_43121 Neighboring gene STARR-seq mESC enhancer starr_43123 Neighboring gene STARR-seq mESC enhancer starr_43125 Neighboring gene predicted gene, 53973 Neighboring gene RIKEN cDNA C030034I22 gene Neighboring gene STARR-seq mESC enhancer starr_43127 Neighboring gene RIKEN cDNA A730049N16 gene Neighboring gene A kinase anchor inhibitor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic cloning and characterization of the mouse POZ/zinc-finger protein ZF5. Yokoro K, et al. Biochem Biophys Res Commun, 1998 May 29. PMID 9618270
    2. Analysis of the consensus binding sequence and the DNA-binding domain of ZF5. Obata T, et al. Biochem Biophys Res Commun, 1999 Feb 16. PMID 10049742
    3. Expression cloning and intracellular localization of a human ZF5 homologue. Sugiura K, et al. Biochim Biophys Acta, 1997 May 2. PMID 9177479
    4. Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins. Numoto M, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8367294, Free PMC Article
    5. ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex. Kim W, et al. Nat Commun, 2019 Nov 22. PMID 31757956, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Chemically induced (ENU) (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart valve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 14
    Names
    zfp-161
    zinc finger protein 161
    zinc finger protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356282.1 → NP_001343211.1  zinc finger and BTB domain-containing protein 14

      Status: VALIDATED

      Source sequence(s)
      AC122487, AK082051, AK136762, AK145517, BC052017, BY070865
      Consensus CDS
      CCDS37682.1
      UniProtKB/Swiss-Prot
      Q08376
      UniProtKB/TrEMBL
      Q544H8
      Related
      ENSMUSP00000054897.8, ENSMUST00000062369.14
      Conserved Domains (4) summary
      COG5189
      Location:303 → 383
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18204
      Location:18 → 131
      BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
      pfam13465
      Location:319 → 344
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001356283.1 → NP_001343212.1  zinc finger and BTB domain-containing protein 14

      Status: VALIDATED

      Source sequence(s)
      AC122487
      Consensus CDS
      CCDS37682.1
      UniProtKB/Swiss-Prot
      Q08376
      UniProtKB/TrEMBL
      Q544H8
      Related
      ENSMUSP00000108294.2, ENSMUST00000112674.8
      Conserved Domains (4) summary
      COG5189
      Location:303 → 383
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18204
      Location:18 → 131
      BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
      pfam13465
      Location:319 → 344
      zf-H2C2_2; Zinc-finger double domain

    3. NM_009547.3 → NP_033573.1  zinc finger and BTB domain-containing protein 14

      See identical proteins and their annotated locations for NP_033573.1

      Status: VALIDATED

      Source sequence(s)
      AK082051, AK136762, BC052017, CB247149
      Consensus CDS
      CCDS37682.1
      UniProtKB/Swiss-Prot
      Q08376
      UniProtKB/TrEMBL
      Q544H8
      Related
      ENSMUSP00000108296.3, ENSMUST00000112676.4
      Conserved Domains (4) summary
      COG5189
      Location:303 → 383
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18204
      Location:18 → 131
      BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
      pfam13465
      Location:319 → 344
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      69690170..69697747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08376.1 GenPept UniProtKB/Swiss-Prot:Q08376

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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