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    CUL2 cullin 2 [ Homo sapiens (human) ]

    Gene ID: 8453, updated on 7-Apr-2024

    Summary

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    Official Symbol
    CUL2provided by HGNC
    Official Full Name
    cullin 2provided by HGNC
    Primary source
    HGNC:HGNC:2552
    See related
    Ensembl:ENSG00000108094 MIM:603135; AllianceGenome:HGNC:2552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Located in nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10p11.21
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (35008551..35127006, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (35037104..35155467, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35297479..35379542, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak929 silencer Neighboring gene long intergenic non-protein coding RNA 2635 Neighboring gene uncharacterized LOC124902409 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:35301624-35302194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35379443-35379631 Neighboring gene microRNA 3611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3260 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3263 Neighboring gene cAMP responsive element modulator Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling. Zheng S, et al. Radiother Oncol, 2021 Jan. PMID 32918970
    2. The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer. Liu X, et al. Adv Exp Med Biol, 2020. PMID 31898228
    3. MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo. Li Y, et al. PeerJ, 2023. PMID 37397007, Free PMC Article
    4. A close shave: How SARS-CoV-2 induces the loss of cilia. Fonseca BF, et al. J Cell Biol, 2022 Jul 4. PMID 35695891, Free PMC Article
    5. CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2. Meng L, et al. Mol Cancer, 2022 Jun 1. PMID 35650603, Free PMC Article

    See all (254) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
      Title: MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
    2. MicroRNA-574-3p Regulates HIF-alpha Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.
      Title: MicroRNA-574-3p Regulates HIF-α Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.
    3. A close shave: How SARS-CoV-2 induces the loss of cilia.
      Title: A close shave: How SARS-CoV-2 induces the loss of cilia.
    4. CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.
      Title: CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.
    5. Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.
      Title: Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.
    6. Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
      Title: Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
    7. Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.
      Title: Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.
    8. ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
      Title: ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
    9. Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer
      Title: The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer.
    10. Twist1 bound the Cul2 promoter.
      Title: Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif is identified to have a physical interaction with Cullin 2 (CUL2) in human HEK293 and/or Jurkat cell lines PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC131970

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination TAS
    Traceable Author Statement
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of VCB complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cullin-2
    Names
    CUL-2
    testis secretory sperm-binding protein Li 238E

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198777.2 → NP_001185706.1  cullin-2 isoform c

      See identical proteins and their annotated locations for NP_001185706.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AI089201, AK095217, AL392046, BC009591
      Consensus CDS
      CCDS7179.1
      UniProtKB/Swiss-Prot
      B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9
      UniProtKB/TrEMBL
      A0A140VKB1, A0A8I5KUA9
      Related
      ENSP00000363883.3, ENST00000374751.7
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:675 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    2. NM_001198778.2 → NP_001185707.1  cullin-2 isoform a

      See identical proteins and their annotated locations for NP_001185707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI089201, AL392046, BC009591, DC401811
      Consensus CDS
      CCDS55709.1
      UniProtKB/TrEMBL
      A0A8I5QJI3
      Related
      ENSP00000414095.2, ENST00000421317.5
      Conserved Domains (2) summary
      pfam00888
      Location:34 → 662
      Cullin; Cullin family
      pfam10557
      Location:696 → 754
      Cullin_Nedd8; Cullin protein neddylation domain

    3. NM_001198779.1 → NP_001185708.1  cullin-2 isoform b

      See identical proteins and their annotated locations for NP_001185708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AI089201, AK310225, AL392046, BC009591, DC401811
      Consensus CDS
      CCDS73086.1
      UniProtKB/TrEMBL
      A0A0A0MTN0, A0A8I5QJI3
      Related
      ENSP00000444856.2, ENST00000537177.6
      Conserved Domains (2) summary
      pfam00888
      Location:28 → 656
      Cullin; Cullin family
      pfam10557
      Location:690 → 748
      Cullin_Nedd8; Cullin protein neddylation domain

    4. NM_001324375.2 → NP_001311304.1  cullin-2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AK294080, AL392046
      Consensus CDS
      CCDS91236.1
      UniProtKB/TrEMBL
      A0A8I5KUA9, A0A8I5KVR3
      Related
      ENSP00000508924.1, ENST00000690123.1

    5. NM_001324376.2 → NP_001311305.1  cullin-2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AK310225, AL392046
      UniProtKB/TrEMBL
      A0A8I5KUA9
      Conserved Domains (2) summary
      pfam00888
      Location:5 → 512
      Cullin; Cullin family
      pfam10557
      Location:546 → 604
      Cullin_Nedd8; Cullin protein neddylation domain

    6. NM_003591.4 → NP_003582.2  cullin-2 isoform c

      See identical proteins and their annotated locations for NP_003582.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AI089201, AL392046, BC009591, DC401936
      Consensus CDS
      CCDS7179.1
      UniProtKB/Swiss-Prot
      B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9
      UniProtKB/TrEMBL
      A0A140VKB1, A0A8I5KUA9
      Related
      ENSP00000363881.3, ENST00000374749.8
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:675 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      35008551..35127006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519745.2 → XP_011518047.1  cullin-2 isoform X1

      See identical proteins and their annotated locations for XP_011518047.1

      UniProtKB/TrEMBL
      A0A8I5QJI3
      Conserved Domains (3) summary
      smart00182
      Location:487 → 631
      CULLIN; Cullin
      smart00884
      Location:735 → 802
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:93 → 706
      Cullin; Cullin family

    2. XM_047425852.1 → XP_047281808.1  cullin-2 isoform X1

    3. XM_011519743.1 → XP_011518045.1  cullin-2 isoform X1

      See identical proteins and their annotated locations for XP_011518045.1

      UniProtKB/TrEMBL
      A0A8I5QJI3
      Conserved Domains (3) summary
      smart00182
      Location:487 → 631
      CULLIN; Cullin
      smart00884
      Location:735 → 802
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:93 → 706
      Cullin; Cullin family

    4. XM_011519744.1 → XP_011518046.1  cullin-2 isoform X1

      See identical proteins and their annotated locations for XP_011518046.1

      UniProtKB/TrEMBL
      A0A8I5QJI3
      Conserved Domains (3) summary
      smart00182
      Location:487 → 631
      CULLIN; Cullin
      smart00884
      Location:735 → 802
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:93 → 706
      Cullin; Cullin family

    5. XM_011519747.2 → XP_011518049.1  cullin-2 isoform X2

      See identical proteins and their annotated locations for XP_011518049.1

      UniProtKB/Swiss-Prot
      B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9
      UniProtKB/TrEMBL
      A0A140VKB1, A0A8I5KUA9
      Related
      ENSP00000363880.1, ENST00000374748.5
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:675 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      35037104..35155467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366953.1 → XP_054222928.1  cullin-2 isoform X1

    2. XM_054366954.1 → XP_054222929.1  cullin-2 isoform X1

    3. XM_054366951.1 → XP_054222926.1  cullin-2 isoform X1

    4. XM_054366952.1 → XP_054222927.1  cullin-2 isoform X1

    5. XM_054366955.1 → XP_054222930.1  cullin-2 isoform X2

      UniProtKB/Swiss-Prot
      B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9
      UniProtKB/TrEMBL
      A0A140VKB1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13617.2 GenPept UniProtKB/Swiss-Prot:Q13617

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