rbp4 retinol binding protein 4, plasma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rbp4provided by ZNC
Official Full Name: retinol binding protein 4, plasmaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000210-19
See related: Ensembl:ENSDARG00000101199 AllianceGenome:ZFIN:ZDB-GENE-000210-19
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rbp; fb23c12; zgc:86911; wu:fb23c12; wu:fb58d04; wu:fb72b04
Summary: Predicted to enable retinol binding activity. Acts upstream of or within liver development and response to retinoic acid. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including apical ectodermal ridge; digestive system; integument; reproductive system; and yolk. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (5115992..5120217, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (5081040..5085231, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these data support the model thatretinol binding protein 4 and retinoic acid precursors are present within the CSF and used for synthesis of retinoic acid, which promotes embryonic neuroepithelial survival
Title: Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway.
STRA6 deficiency lead to accumulation of RBP-4 bound vitamin A and developmental abnormalities.
Title: RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome.
YSL-expressed Rbp4 plays a role in formation of both yolk extension and liver bud, the latter may also require migration of liver progenitor cells
Title: Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development.

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General gene information

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Markers

fb72b04 (e-PCR)
- UniSTS:187405

fb72b04.x1 (e-PCR)
- UniSTS:191082

STS.70G6 (e-PCR)
- UniSTS:205695

AI476999 (e-PCR)
- UniSTS:206539

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables retinoid binding	IEA Inferred from Electronic Annotation more info
enables retinol binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinol binding	IEA Inferred from Electronic Annotation more info
enables retinol transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: retinol-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130920.2 → NP_570995.1 retinol-binding protein 4 precursor

See identical proteins and their annotated locations for NP_570995.1

Status: VALIDATED

Source sequence(s)

BC075787

UniProtKB/TrEMBL

A3FFK7, Q9PT95

Related

ENSDARP00000141692.1, ENSDART00000168759.2

Conserved Domains (1) summary

pfam00061
Location:36 → 162

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

5115992..5120217 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480010.1 → XP_021335685.1 retinol-binding protein 4 isoform X1

UniProtKB/TrEMBL

A3FFK7, Q9PT95

Conserved Domains (1) summary

pfam00061
Location:36 → 162

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family