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    Itprip inositol 1,4,5-triphosphate receptor interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 414801, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Itpripprovided by MGI
    Official Full Name
    inositol 1,4,5-triphosphate receptor interacting proteinprovided by MGI
    Primary source
    MGI:MGI:3042776
    See related
    Ensembl:ENSMUSG00000117975 AllianceGenome:MGI:3042776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DANGER; 4833424O12Rik
    Summary
    Enables protein kinase inhibitor activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in nuclear outer membrane. Orthologous to human ITPRIP (inositol 1,4,5-trisphosphate receptor interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 19.7), thymus adult (RPKM 12.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 D1; 19 40.49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47883029..47907738, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47894590..47919323, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1529 Neighboring gene STARR-positive B cell enhancer ABC_E1530 Neighboring gene STARR-positive B cell enhancer ABC_E7670 Neighboring gene VISTA enhancer mm324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47993319-47993502 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47994118-47994301 Neighboring gene STARR-positive B cell enhancer mm9_chr19:48011969-48012270 Neighboring gene glutathione S-transferase omega 1 Neighboring gene glutathione S-transferase omega 2 Neighboring gene cilia and flagella associated protein 58 Neighboring gene STARR-seq mESC enhancer starr_46376 Neighboring gene STARR-seq mESC enhancer starr_46378 Neighboring gene sortilin-related VPS10 domain containing receptor 3 Neighboring gene STARR-seq mESC enhancer starr_46379 Neighboring gene STARR-seq mESC enhancer starr_46381 Neighboring gene STARR-seq mESC enhancer starr_46382

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization. Liu Q, et al. Mol Cells, 2015 Oct. PMID 26429502, Free PMC Article
    2. Death-associated protein kinase-mediated cell death modulated by interaction with DANGER. Kang BN, et al. J Neurosci, 2010 Jan 6. PMID 20053891, Free PMC Article
    3. Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells. Cheng LC, et al. Nucleus, 2019 Dec. PMID 31142202, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1754, mKIAA1754

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol 1,4,5-trisphosphate receptor-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001738.4 → NP_001001738.2  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

      See identical proteins and their annotated locations for NP_001001738.2

      Status: VALIDATED

      Source sequence(s)
      AC126679
      Consensus CDS
      CCDS29895.1
      UniProtKB/Swiss-Prot
      Q3TAD9, Q3TB01, Q3TNL8, Q571G7, Q6P400
      Related
      ENSMUSP00000093697.6, ENSMUST00000095998.7
      Conserved Domains (2) summary
      pfam03281
      Location:377 → 485
      Mab-21; Mab-21 protein
      pfam06098
      Location:34 → 67
      Radial_spoke_3; Radial spoke protein 3

    2. NM_001362458.2 → NP_001349387.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC126679
      Consensus CDS
      CCDS29895.1
      UniProtKB/Swiss-Prot
      Q3TAD9, Q3TB01, Q3TNL8, Q571G7, Q6P400
      Conserved Domains (2) summary
      pfam03281
      Location:377 → 485
      Mab-21; Mab-21 protein
      pfam06098
      Location:34 → 67
      Radial_spoke_3; Radial spoke protein 3

    3. NM_001362459.2 → NP_001349388.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC126679
      Consensus CDS
      CCDS29895.1
      UniProtKB/Swiss-Prot
      Q3TAD9, Q3TB01, Q3TNL8, Q571G7, Q6P400
      Conserved Domains (2) summary
      pfam03281
      Location:377 → 485
      Mab-21; Mab-21 protein
      pfam06098
      Location:34 → 67
      Radial_spoke_3; Radial spoke protein 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47883029..47907738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161623.1 → XP_036017516.1  inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      Q3TAD9, Q3TB01, Q3TNL8, Q571G7, Q6P400
      Conserved Domains (2) summary
      pfam03281
      Location:377 → 485
      Mab-21; Mab-21 protein
      pfam06098
      Location:34 → 67
      Radial_spoke_3; Radial spoke protein 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TNL8.1 GenPept UniProtKB/Swiss-Prot:Q3TNL8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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