Gadl1 glutamate decarboxylase-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gadl1provided by MGI
Official Full Name: glutamate decarboxylase-like 1provided by MGI
Primary source: MGI:MGI:1920998
See related: Ensembl:ENSMUSG00000056880 AllianceGenome:MGI:1920998
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADC; CSADC; 1110027M19Rik
Summary: Predicted to enable aspartate 1-decarboxylase activity; pyridoxal phosphate binding activity; and sulfinoalanine decarboxylase activity. Predicted to be involved in carboxylic acid metabolic process. Orthologous to human GADL1 (glutamate decarboxylase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 68.25 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (115713739..115905244)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (115884671..116076176)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure of GADL1 is described, together with a solution model based on small-angle X-ray scattering data. While the overall fold and the conformation of the bound PLP are similar to those in other PLP-dependent decarboxylases, GADL1 adopts a more loose conformation in solution, which might have functional relevance in ligand binding and catalysis.
Title: Structure of the mouse acidic amino acid decarboxylase GADL1.
taurine biosynthesis in vertebrates involves two structurally related PLP-dependent decarboxylases (cysteine sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
Title: Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression.
analysis of the role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis
Title: Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit215 (e-PCR), detects polymorphism
- UniSTS:131773

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartate 1-decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables sulfinoalanine decarboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acidic amino acid decarboxylase GADL1

Names: aspartate 1-decarboxylase; cysteine sulfinic acid decarboxylase; glutamate decarboxylase-like protein 1

NP_001382689.1

EC 4.1.1.11

EC 4.1.1.29

NP_082914.1

EC 4.1.1.11

EC 4.1.1.29

XP_006512382.1

EC 4.1.1.11

EC 4.1.1.29

XP_036011234.1

EC 4.1.1.11

EC 4.1.1.29

XP_036011235.1

EC 4.1.1.11

EC 4.1.1.29

XP_036011236.1

EC 4.1.1.11

EC 4.1.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395760.1 → NP_001382689.1 acidic amino acid decarboxylase GADL1 isoform 1

Status: VALIDATED

Source sequence(s)

AC131777, AC133169, AC167467

UniProtKB/Swiss-Prot

Q80WP8, Q9CTD2

UniProtKB/TrEMBL

K4DI69

Related

ENSMUSP00000077694.7, ENSMUST00000069651.14

Conserved Domains (1) summary

cd06450
Location:118 → 518

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
NM_028638.1 → NP_082914.1 acidic amino acid decarboxylase GADL1 isoform 2

Status: VALIDATED

Source sequence(s)

AC131777, AK003937, BC052327

Consensus CDS

CCDS52954.1

UniProtKB/Swiss-Prot

Q80WP8, Q9CTD2

UniProtKB/TrEMBL

A0A8Q0QWL6

Related

ENSMUSP00000159481.1, ENSMUST00000240548.1

Conserved Domains (1) summary

cd06450
Location:98 → 498

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

115713739..115905244

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512319.4 → XP_006512382.1 acidic amino acid decarboxylase GADL1 isoform X2

See identical proteins and their annotated locations for XP_006512382.1

UniProtKB/Swiss-Prot

Q80WP8, Q9CTD2

Conserved Domains (1) summary

cd06450
Location:114 → 514

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_036155341.1 → XP_036011234.1 acidic amino acid decarboxylase GADL1 isoform X2

UniProtKB/Swiss-Prot

Q80WP8, Q9CTD2

Related

ENSMUSP00000113240.3, ENSMUST00000121770.3

Conserved Domains (1) summary

cd06450
Location:114 → 514

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_036155342.1 → XP_036011235.1 acidic amino acid decarboxylase GADL1 isoform X3

UniProtKB/Swiss-Prot

Q80WP8, Q9CTD2

Conserved Domains (1) summary

cl18945
Location:78 → 436

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_036155343.1 → XP_036011236.1 acidic amino acid decarboxylase GADL1 isoform X4

Conserved Domains (1) summary

cl18945
Location:27 → 282

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...