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    Rnls renalase, FAD-dependent amine oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361751, updated on 31-Mar-2024

    Summary

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    Official Symbol
    Rnlsprovided by RGD
    Official Full Name
    renalase, FAD-dependent amine oxidaseprovided by RGD
    Primary source
    RGD:1309804
    See related
    Ensembl:ENSRNOG00000020705 AllianceGenome:RGD:1309804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309804
    Summary
    Predicted to enable several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in response to epinephrine; response to ischemia; and response to salt. Located in extracellular space. Biomarker of chronic kidney disease; congestive heart failure; glomerulosclerosis; and interstitial nephritis. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human RNLS (renalase, FAD dependent amine oxidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 38.8), Kidney (RPKM 31.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnls in Genome Data Viewer
    Location:
    1q52
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (240450702..240723472, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (231037481..231309855, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (251828285..252101963, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547905 Neighboring gene aldo-keto reductase family 1, member B8, pseudogene 1 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene uncharacterized LOC102548095 Neighboring gene small nucleolar RNA SNORA8 Neighboring gene U4 spliceosomal RNA Neighboring gene ribosomal protein S4, X-linked, pseudogene 1 Neighboring gene lipase, member O1 Neighboring gene lipase family member J

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Moderate-intensity exercise increases renalase levels in the blood and skeletal muscle of rats. Tokinoya K, et al. FEBS Open Bio, 2020 Jun. PMID 32053739, Free PMC Article
    2. Exercise differentially regulates renalase expression in skeletal muscle and kidney. Czarkowska-Paczek B, et al. Tohoku J Exp Med, 2013 Dec. PMID 24366404
    3. Renalase mRNA levels in the brain, heart, and kidneys of spontaneously hypertensive rats with moderate and high hypertension. Fedchenko V, et al. Med Sci Monit Basic Res, 2013 Oct 11. PMID 24113803, Free PMC Article
    4. Lisinopril protects against the adriamycin nephropathy and reverses the renalase reduction: potential role of renalase in adriamycin nephropathy. Han P, et al. Kidney Blood Press Res, 2013. PMID 24022426
    5. Renalase protects against ischemic AKI. Lee HT, et al. J Am Soc Nephrol, 2013 Feb. PMID 23393318, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Investigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Model.
      Title: Investigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Model.
    2. Renalase regulates renal tubular injury in diabetic nephropathy via the p38MAPK signaling pathway.
      Title: Renalase regulates renal tubular injury in diabetic nephropathy via the p38MAPK signaling pathway.
    3. Moderate-intensity exercise increases renalase levels in the blood and skeletal muscle of rats.
      Title: Moderate-intensity exercise increases renalase levels in the blood and skeletal muscle of rats.
    4. Findings suggest that hypoxia-inducible factor-1alpha (HIF-1alpha) up-regulated renalase directly in hypoxia.
      Title: Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α.
    5. The brain and peripheral tissues renalase mRNA levels demonstrate opposite trends, which are obviously crucial for impaired regulation of blood pressure in spontaneously hypertensive rats.
      Title: Renalase mRNA levels in the brain, heart, and kidneys of spontaneously hypertensive rats with moderate and high hypertension.
    6. exercise differentially regulates renalase expression in skeletal muscle and kidney in rats
      Title: Exercise differentially regulates renalase expression in skeletal muscle and kidney.
    7. Renalase deficiency occurs in salt-sensitive Dahl rats as they develop hypertension[review]
      Title: Renalase, a new renal hormone: its role in health and disease.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables epinephrine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac left ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within norepinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to catecholamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to epinephrine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to norepinephrine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to salt IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    renalase
    Names
    MAO-C
    alpha-NAD(P)H oxidase/anomerase
    monoamine oxidase-C
    NP_001014189.1
    NP_001386617.1
    XP_006231356.1
    XP_038940436.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014167.2 → NP_001014189.1  renalase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001014189.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5U2W9
      Related
      ENSRNOP00000028098.5, ENSRNOT00000028098.6
      Conserved Domains (2) summary
      pfam13450
      Location:6 → 80
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:107 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001399688.1 → NP_001386617.1  renalase isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Conserved Domains (1) summary
      COG3380
      Location:1 → 342
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      240450702..240723472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231294.3 → XP_006231356.1  renalase isoform X1

      See identical proteins and their annotated locations for XP_006231356.1

      Conserved Domains (1) summary
      COG3380
      Location:1 → 342
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]

    2. XM_039084508.2 → XP_038940436.1  renalase isoform X2

      Conserved Domains (1) summary
      COG3380
      Location:1 → 231
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]

    RNA

    1. XR_010055152.1 RNA Sequence

    2. XR_005489056.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2W9.1 GenPept UniProtKB/Swiss-Prot:Q5U2W9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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