Psmc5 proteasome 26S subunit, ATPase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psmc5provided by RGD
Official Full Name: proteasome 26S subunit, ATPase 5provided by RGD
Primary source: RGD:708376
See related: Ensembl:ENSRNOG00000010038 AllianceGenome:RGD:708376
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sug1
Summary: Enables ATP hydrolysis activity and TBP-class protein binding activity. Involved in modulation of chemical synaptic transmission and positive regulation of inclusion body assembly. Located in inclusion body; nucleus; and postsynapse. Part of cytosolic proteasome complex and nuclear proteasome complex. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 424.5), Heart (RPKM 399.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91687553..91693487)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (91187763..91193697)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94445877..94451811)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia-induced increase in Sug1 leads to poor post-transplantation survival of allogeneic mesenchymal stem cells.
Title: Hypoxia-induced increase in Sug1 leads to poor post-transplantation survival of allogeneic mesenchymal stem cells.
Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation.
Title: Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation.
CaMKII-dependent phosphorylation of Rpt6 at S120 may be an important regulatory mechanism for proteasome-dependent control of synaptic remodeling in slow homeostatic plasticity
Title: Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons.
cyclic AMP-dependent protein kinase regulates proteasome function through phosphorylation of Rpt6
Title: Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M60510 (e-PCR)
- UniSTS:124962

MARC_4113-4114:991938380:3 (e-PCR)
- UniSTS:231072

MARC_4113-4114:996679383:1 (e-PCR)
- UniSTS:231072

RH136975 (e-PCR)
- UniSTS:219064

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables general transcription initiation factor binding	IEA Inferred from Electronic Annotation more info
enables general transcription initiation factor binding	ISO Inferred from Sequence Orthology more info
enables general transcription initiation factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables thyrotropin-releasing hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables thyrotropin-releasing hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables thyrotropin-releasing hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inclusion body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IC Inferred by Curator more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
part_of cytosolic proteasome complex	IDA Inferred from Direct Assay more info	PubMed
located_in inclusion body	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear proteasome complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome accessory complex	ISO Inferred from Sequence Orthology more info
part_of proteasome accessory complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome regulatory particle	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome regulatory subunit 8

Names: 26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; TRIP1; for proteasomal ATPase (SUG1); p45/SUG; peptidase (prosome, macropain) 26S subunit, ATPase 5; protease (prosome, macropain) 26S subunit, ATPase 5; proteasomal ATPase (SUG1); proteasome (prosome, macropain) 26S subunit, ATPase, 5; proteasome p45/SUG; proteasome subunit p45; thyroid hormone receptor-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031149.1 → NP_112411.1 26S proteasome regulatory subunit 8

See identical proteins and their annotated locations for NP_112411.1

Status: PROVISIONAL

Source sequence(s)

AB000491

UniProtKB/Swiss-Prot

P62198

UniProtKB/TrEMBL

A0A8L2Q7I4, A6HK17

Related

ENSRNOP00000013997.4, ENSRNOT00000013997.7

Conserved Domains (1) summary

COG1222
Location:4 → 404

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]