Tas1r3 taste 1 receptor member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tas1r3provided by RGD
Official Full Name: taste 1 receptor member 3provided by RGD
Primary source: RGD:620539
See related: Ensembl:ENSRNOG00000019589 AllianceGenome:RGD:620539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: T1r3
Summary: Enables taste receptor activity. Involved in sensory perception of sweet taste and sensory perception of umami taste. Predicted to be integral component of membrane. Predicted to be part of sweet taste receptor complex. Predicted to be integral component of plasma membrane. Orthologous to human TAS1R3 (taste 1 receptor member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 66.1), Liver (RPKM 53.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (171750937..171754993, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (166468703..166472759, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (173307325..173312950, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring.
Title: Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring.
Our research indicates that the T1R1/T1R3 receptor is an anti-inflammatory receptor for infiltrating granulocytes after spinal cord injury
Title: T1R1/T1R3 Taste Receptor Suppresses Granulocyte-Mediated Neuroinflammation after Spinal Cord Injury.
Sweet taste molecules of T1R2, T1R3, alpha-gustducin and TRPM5 in ileum were dramatically higher than those in duodenum (P<0.01 for each).
Title: Expression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes.
Low concentration of endogenous GC is necessary and sufficient for induction of T1R3 expression. Higher concentrations may inhibit such induction. This inhibitory effect may be due, at least in part, to a direct action of GC on taste cells.
Title: Involvement of glucocorticoid in induction of lingual T1R3 in rodents.
T1R3 is expressed mainly in beta-cells and the expression levels are different depending upon the nutritional and metabolic conditions.
Title: Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states.
results suggest that nutritional status alters saccharin preference and the expression of T1R3 in taste buds; these processes may be involved in the mechanisms underlying the modulation of peripheral sweet taste sensitivity, in which leptin plays a role
Title: Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to sweet taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to sweet taste receptor activity	ISO Inferred from Sequence Orthology more info
enables taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables taste receptor activity	IPI Inferred from Physical Interaction more info	PubMed
contributes_to taste receptor activity	ISO Inferred from Sequence Orthology more info
enables taste receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus involved in sensory perception of sweet taste	TAS Traceable Author Statement more info	PubMed
involved_in sensory perception of sweet taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sweet taste	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of umami taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of umami taste	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of umami taste	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of sweet taste receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: taste receptor type 1 member 3

Names: sweet taste receptor T1R3; taste receptor, type 1, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130818.2 → NP_570831.1 taste receptor type 1 member 3 precursor

See identical proteins and their annotated locations for NP_570831.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q923K1

UniProtKB/TrEMBL

A6IUT6

Related

ENSRNOP00000026671.1, ENSRNOT00000026671.3

Conserved Domains (4) summary

pfam00003
Location:595 → 821

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:73 → 469

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:501 → 551

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:29 → 494

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily