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    Plekhn1 pleckstrin homology domain containing N1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298694, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plekhn1provided by RGD
    Official Full Name
    pleckstrin homology domain containing N1provided by RGD
    Primary source
    RGD:1311019
    See related
    Ensembl:ENSRNOG00000020295 AllianceGenome:RGD:1311019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311019
    Summary
    Predicted to enable phospholipid binding activity. Predicted to be involved in 3'-UTR-mediated mRNA destabilization; positive regulation of apoptotic process; and response to hypoxia. Predicted to be located in mitochondrion. Predicted to be active in cytoskeleton and mitochondrial membrane. Orthologous to human PLEKHN1 (pleckstrin homology domain containing N1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 37.2), Lung (RPKM 23.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhn1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (172087524..172095566, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166805309..166813339, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173646055..173654140, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene agrin Neighboring gene ISG15 ubiquitin-like modifier Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1 Neighboring gene kelch-like family member 17 Neighboring gene NOC2-like nucleolar associated transcriptional repressor Neighboring gene sterile alpha motif domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of N-myristoylation in stability and subcellular localization of the CLPABP protein. Maeda A, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29180010
    2. Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule. Sano E, et al. Biochim Biophys Acta, 2008 Jun. PMID 18191643
    3. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Nishino T, et al. Biochim Biophys Acta, 2016 Nov. PMID 27616329
    4. PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. Kuriyama S, et al. Cell Death Discov, 2018 Dec. PMID 29531808, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cardiolipin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cardiolipin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family N member 1
    Names
    pleckstrin homology domain containing, family N member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134523.1 → NP_001127995.1  pleckstrin homology domain-containing family N member 1

      See identical proteins and their annotated locations for NP_001127995.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IUW8, D3Z815
      Related
      ENSRNOP00000031799.4, ENSRNOT00000038556.5
      Conserved Domains (2) summary
      cd13323
      Location:222 → 341
      PH_PLEKHN1; Pleckstrin homology domain containing family N member 1Pleckstrin homology-like domain
      cl17171
      Location:96 → 188
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      172087524..172095566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239565.5 → XP_006239627.1  pleckstrin homology domain-containing family N member 1 isoform X2

      See identical proteins and their annotated locations for XP_006239627.1

      UniProtKB/TrEMBL
      A6IUW9
      Conserved Domains (2) summary
      cd13323
      Location:222 → 341
      PH_PLEKHN1; Pleckstrin homology domain containing family N member 1Pleckstrin homology-like domain
      cl17171
      Location:96 → 188
      PH-like; Pleckstrin homology-like domain

    2. XM_006239564.5 → XP_006239626.1  pleckstrin homology domain-containing family N member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUH3
      Related
      ENSRNOP00000082942.1
      Conserved Domains (2) summary
      cd13323
      Location:222 → 341
      PH_PLEKHN1; Pleckstrin homology domain containing family N member 1Pleckstrin homology-like domain
      cl17171
      Location:96 → 188
      PH-like; Pleckstrin homology-like domain

    3. XM_063287515.1 → XP_063143585.1  pleckstrin homology domain-containing family N member 1 isoform X4

    4. XM_039109730.2 → XP_038965658.1  pleckstrin homology domain-containing family N member 1 isoform X3

      Conserved Domains (1) summary
      cd13323
      Location:34 → 153
      PH_PLEKHN1; Pleckstrin homology domain containing family N member 1Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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