U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Atg101 Autophagy-related 101 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32871, updated on 4-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Atg101provided by FlyBase
    Official Full Name
    Autophagy-related 101provided by FlyBase
    Primary source
    FLYBASE:FBgn0030960
    Locus tag
    Dmel_CG7053
    See related
    AllianceGenome:FB:FBgn0030960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atg101; ATG101; CG7053; Dmel\CG7053
    Summary
    Enables protein domain specific binding activity and protein kinase binding activity. Involved in autophagy; larval midgut cell programmed cell death; and positive regulation of macroautophagy. Part of Atg1/ULK1 kinase complex. Is expressed in gonad and organism. Orthologous to human ATG101 (autophagy related 101). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    17D6-17D6; 1-60 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18791668..18793517)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18685701..18687550)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene S6 Kinase Like Neighboring gene bangles and beads Neighboring gene antisense RNA:CR44841

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Analysis of Drosophila Atg8 proteins reveals multiple lipidation-independent roles. Jipa A, et al. Autophagy, 2021 Sep. PMID 33249988, Free PMC Article
    2. The autophagy-related gene Atg101 in Drosophila regulates both neuron and midgut homeostasis. Guo T, et al. J Biol Chem, 2019 Apr 5. PMID 30760524, Free PMC Article
    3. The putative HORMA domain protein Atg101 dimerizes and is required for starvation-induced and selective autophagy in Drosophila. Hegedűs K, et al. Biomed Res Int, 2014. PMID 24895579, Free PMC Article
    4. Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila. Nagy P, et al. Autophagy, 2014 Mar. PMID 24419107, Free PMC Article
    5. PP2A regulates autophagy in two alternative ways in Drosophila. Bánréti Á, et al. Autophagy, 2012 Apr. PMID 22330894

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the results of study indicate that Drosophila Atg101 is essential for tissue homeostasis in both adult brains and midguts.
      Title: The autophagy-related gene Atg101 in Drosophila regulates both neuron and midgut homeostasis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval midgut histolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Atg1/ULK1 kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Autophagy-related 101
    Names
    Atg101-PA
    Autophagy-specific gene 101
    CG7053-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18791668..18793517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133098.3 → NP_573326.1  Autophagy-related 101 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573326.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWQ1
      Related
      FBpp0074406
      Conserved Domains (1) summary
      pfam07855
      Location:9 → 172
      ATG101; Autophagy-related protein 101
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWQ1 Q9VWQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous