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    SERPINH1 serpin family H member 1 [ Gallus gallus (chicken) ]

    Gene ID: 396228, updated on 3-Apr-2024

    Summary

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    Official Symbol
    SERPINH1provided by CGNC
    Official Full Name
    serpin family H member 1provided by CGNC
    Primary source
    CGNC:8518
    See related
    Ensembl:ENSGALG00010002923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    HSP47
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (195370322..195377125, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (195237186..195244026, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD15 Neighboring gene small nucleolar RNA SNORD15 Neighboring gene uncharacterized LOC101751623 Neighboring gene ribosomal protein S3 Neighboring gene uncharacterized LOC121109258 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum. Ishikawa Y, et al. J Biol Chem, 2017 Oct 20. PMID 28860186, Free PMC Article
    2. Characterization of a novel transformation-sensitive heat-shock protein (HSP47) that binds to collagen. Nagata K, et al. Biochem Biophys Res Commun, 1988 May 31. PMID 3377793
    3. HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts. Hirayoshi K, et al. Mol Cell Biol, 1991 Aug. PMID 2072906, Free PMC Article
    4. Conserved BK channel-protein interactions reveal signals relevant to cell death and survival. Sokolowski B, et al. PLoS One, 2011. PMID 22174833, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that a weak interaction between Hsp47 and FKBP65 confers mutual molecular stability and also allows for a synergistic effect during collagen folding.
      Title: Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen fibril organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin H1
    Names
    47 kDa heat shock protein
    collagen-binding protein
    colligin
    heat shock protein 47
    serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
    serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396972.1 → NP_001383901.1  serpin H1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000032
      UniProtKB/Swiss-Prot
      P13731, P29042
      UniProtKB/TrEMBL
      A0A8V0XBU4

    2. NM_205291.2 → NP_990622.1  serpin H1 precursor

      See identical proteins and their annotated locations for NP_990622.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000032
      UniProtKB/Swiss-Prot
      P13731, P29042
      UniProtKB/TrEMBL
      A0A8V0XBU4
      Related
      ENSGALP00010004137.1, ENSGALT00010006788.1
      Conserved Domains (1) summary
      cd02046
      Location:23 → 404
      serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      195370322..195377125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040665757.2 → XP_040521691.1  serpin H1 isoform X1

      UniProtKB/Swiss-Prot
      P13731, P29042
      UniProtKB/TrEMBL
      A0A8V0XBU4
      Conserved Domains (1) summary
      cd02046
      Location:23 → 404
      serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      195237186..195244026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906875.1 → XP_046762831.1  serpin H1 isoform X1

      UniProtKB/Swiss-Prot
      P13731, P29042
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13731.2 GenPept UniProtKB/Swiss-Prot:P13731

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.