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    Krt72 keratin 72 [ Mus musculus (house mouse) ]

    Gene ID: 105866, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Krt72provided by MGI
    Official Full Name
    keratin 72provided by MGI
    Primary source
    MGI:MGI:2146034
    See related
    Ensembl:ENSMUSG00000056605 AllianceGenome:MGI:2146034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K72; CK-72; K6irs2; Krt2-35; Krt72-ps
    Summary
    Predicted to be located in keratin filament. Is expressed in vibrissa. Orthologous to human KRT72 (keratin 72). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F2; 15 57.02 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101684607..101694955, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101776172..101786520, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 71 Neighboring gene keratin 74 Neighboring gene STARR-seq mESC enhancer starr_39803 Neighboring gene STARR-seq mESC enhancer starr_39804 Neighboring gene keratin 73 Neighboring gene keratin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. Blanco S, et al. PLoS Genet, 2011 Dec. PMID 22144916, Free PMC Article
    2. iRhom2 mutation leads to aberrant hair follicle differentiation in mice. Leilei Y, et al. PLoS One, 2014. PMID 25546423, Free PMC Article
    3. Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion. Sardella C, et al. J Invest Dermatol, 2018 Mar. PMID 28964716, Free PMC Article
    4. Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Wu X, et al. Genes Dev, 2006 Mar 1. PMID 16510873, Free PMC Article
    5. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cytoskeletal 72
    Names
    cytokeratin-72
    keratin 72, pseudogene
    keratin complex 2, basic, gene 35
    type II inner root sheath-specific keratin-K6irs2
    type-II keratin Kb35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213728.2 → NP_998893.1  keratin, type II cytoskeletal 72

      See identical proteins and their annotated locations for NP_998893.1

      Status: VALIDATED

      Source sequence(s)
      AA717861, AC104862, BK001584
      Consensus CDS
      CCDS27863.1
      UniProtKB/Swiss-Prot
      Q6IME9
      Related
      ENSMUSP00000065922.5, ENSMUST00000071104.6
      Conserved Domains (4) summary
      pfam00038
      Location:133 → 446
      Filament; Intermediate filament protein
      pfam05098
      Location:184 → 313
      LEF-4; Late expression factor 4 (LEF-4)
      pfam16208
      Location:15 → 130
      Keratin_2_head; Keratin type II head
      cl09176
      Location:300 → 429
      FlgN; FlgN protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101684607..101694955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IME9.1 GenPept UniProtKB/Swiss-Prot:Q6IME9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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