Eif4b eukaryotic translation initiation factor 4B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif4bprovided by MGI
Official Full Name: eukaryotic translation initiation factor 4Bprovided by MGI
Primary source: MGI:MGI:95304
See related: Ensembl:ENSMUSG00000058655 AllianceGenome:MGI:95304
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eif4a2; 2310046H11Rik
Summary: Predicted to enable RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Predicted to act upstream of or within translational initiation. Predicted to be located in cytosol; dendrite; and neuronal cell body. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 66.8), placenta adult (RPKM 58.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.26 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101982208..102005608)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102073773..102097173)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Title: Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity.
Title: Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity.
PKR inhibition reduced the expression of eIF4B and C/EBPbeta in an eIF2alpha-independent manner
Title: C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation.
Maintenance of eIF4E interaction with eIF4G was not by itself sufficient to sustain global rates of protein synthesis in the absence of mTORC1 signaling to p70S6K1; phosphorylation of both eIF4B and PDCD4 was additionally required.
Title: Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.
C-loops bind to eIF4B and prevent the factor's interaction with 18S rRNA of the small ribosomal subunit.
Title: Dual nature of translational control by regulatory BC RNAs.
Results establish critical roles for S6K and RSK in the induction of IFN-dependent biological effects and define a key regulatory role for eIF4B as a common mediator and integrator of IFN-generated signals from these kinases.
Title: Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals.
These data provide novel insights into complex multikinase regulation of eIF4B phosphorylation and reveal an important mechanism by which PKB can regulate translation, potentially critical for the transforming capacity of this AGC kinase family member.
Title: AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B.
Phosphorylation of eIF4B on Ser422 by p90 ribosomal protein S6 kinase (RSK) and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3.
Title: The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127149 (e-PCR)
- UniSTS:209792

RH125478 (e-PCR)
- UniSTS:162297

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4B

Names: eIF-4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145625.3 → NP_663600.2 eukaryotic translation initiation factor 4B

See identical proteins and their annotated locations for NP_663600.2

Status: VALIDATED

Source sequence(s)

AK045250, CD563487, CO043713

Consensus CDS

CCDS49737.1

UniProtKB/Swiss-Prot

Q3TD64, Q8BGD9

UniProtKB/TrEMBL

Q3TSY9, Q3UGC0

Related

ENSMUSP00000127774.2, ENSMUST00000169681.3

Conserved Domains (3) summary

COG0724
Location:83 → 256

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12402
Location:95 → 171

RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

pfam08648
Location:225 → 290

DUF1777; Protein of unknown function (DUF1777)