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    Nanp N-acetylneuraminic acid phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 67311, updated on 9-May-2024

    Summary

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    Official Symbol
    Nanpprovided by MGI
    Official Full Name
    N-acetylneuraminic acid phosphataseprovided by MGI
    Primary source
    MGI:MGI:1914561
    See related
    Ensembl:ENSMUSG00000053916 AllianceGenome:MGI:1914561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hdhd4; 1600031M04Rik
    Summary
    Predicted to enable N-acylneuraminate-9-phosphatase activity. Predicted to be involved in N-acetylneuraminate biosynthetic process. Predicted to act upstream of or within dephosphorylation. Is expressed in several structures, including alimentary system; liver; and telencephalon ventricular layer. Orthologous to human NANP (N-acetylneuraminic acid phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 18.1), liver E14.5 (RPKM 15.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nanp in Genome Data Viewer
    Location:
    2 G3; 2 74.83 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150871605..150881299, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151029685..151039379, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E-binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06020 Neighboring gene ninein-like Neighboring gene STARR-seq mESC enhancer starr_06023 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3410 Neighboring gene STARR-seq mESC enhancer starr_06026 Neighboring gene predicted gene, 22187 Neighboring gene predicted gene, 24199

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103377

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acylneuraminate-9-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylneuraminate-9-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylneuraminate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    N-acylneuraminate-9-phosphatase
    Names
    haloacid dehalogenase-like hydrolase domain containing 4
    haloacid dehalogenase-like hydrolase domain-containing protein 4
    neu5Ac-9-Pase
    NP_080362.1
    XP_006500131.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026086.2 → NP_080362.1  N-acylneuraminate-9-phosphatase

      See identical proteins and their annotated locations for NP_080362.1

      Status: VALIDATED

      Source sequence(s)
      AL808125, BC083086
      Consensus CDS
      CCDS16864.1
      UniProtKB/Swiss-Prot
      Q9CPT3
      Related
      ENSMUSP00000063895.5, ENSMUST00000066640.5
      Conserved Domains (2) summary
      TIGR02253
      Location:6 → 234
      CTE7; HAD superfamily (subfamily IA) hydrolase, TIGR02253
      cl21460
      Location:114 → 239
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150871605..150881299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500068.4 → XP_006500131.1  N-acylneuraminate-9-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_006500131.1

      Conserved Domains (1) summary
      TIGR02253
      Location:20 → 226
      CTE7; HAD superfamily (subfamily IA) hydrolase, TIGR02253
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPT3.1 GenPept UniProtKB/Swiss-Prot:Q9CPT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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