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    AIDA axin interactor, dorsalization associated [ Homo sapiens (human) ]

    Gene ID: 64853, updated on 7-Apr-2024

    Summary

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    Official Symbol
    AIDAprovided by HGNC
    Official Full Name
    axin interactor, dorsalization associatedprovided by HGNC
    Primary source
    HGNC:HGNC:25761
    See related
    Ensembl:ENSG00000186063 MIM:612375; AllianceGenome:HGNC:25761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1orf80
    Summary
    Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within negative regulation of JUN kinase activity. Predicted to be located in cytoplasm. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 42.6), testis (RPKM 31.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (222668013..222712491, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (221901757..221946247, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222841355..222885833, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222763242-222763775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:222763776-222764308 Neighboring gene TAF1A antisense RNA 1 Neighboring gene H3K27me3-DHS negatively-acting regulatory element H1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:222791257-222792139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2577 Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene prefoldin subunit 5-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:222816645-222817522 and GRCh37_chr1:222817523-222818398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2581 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5183 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:222885601-222886515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5205 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222909786-222910327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1836 Neighboring gene family with sequence similarity 177 member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene. Lalonde S, et al. Genome Biol, 2019 Jul 8. PMID 31287004, Free PMC Article
    2. MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation. Zhang P, et al. Int Heart J, 2022. PMID 36184552
    3. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Rui Y, et al. Dev Cell, 2007 Aug. PMID 17681137
    4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
    5. Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Zang W, et al. Proc Natl Acad Sci U S A, 2019 Dec 17. PMID 31796584, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation.
      Title: MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation.
    2. genetic variant acts in the vascular endothelium to modulate inter-individual risk in coronary artery disease
      Title: Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12806, FLJ32421

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of ventral identity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dorsal/ventral pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    axin interactor, dorsalization-associated protein
    Names
    axin interaction partner and dorsalization antagonist

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022831.4 → NP_073742.2  axin interactor, dorsalization-associated protein

      See identical proteins and their annotated locations for NP_073742.2

      Status: VALIDATED

      Source sequence(s)
      AL392172, AL592148
      Consensus CDS
      CCDS1533.1
      UniProtKB/Swiss-Prot
      A8K1F0, Q49A81, Q5JRA4, Q658P1, Q96BJ3, Q9H9E8
      UniProtKB/TrEMBL
      B7ZW30
      Related
      ENSP00000339161.6, ENST00000340020.11
      Conserved Domains (2) summary
      pfam08910
      Location:9 → 112
      Aida_N; Aida N-terminus
      pfam14186
      Location:162 → 300
      Aida_C2; Cytoskeletal adhesion

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      222668013..222712491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428100.1 → XP_047284056.1  axin interactor, dorsalization-associated protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      221901757..221946247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338316.1 → XP_054194291.1  axin interactor, dorsalization-associated protein isoform X2

    2. XM_054338315.1 → XP_054194290.1  axin interactor, dorsalization-associated protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BJ3.1 GenPept UniProtKB/Swiss-Prot:Q96BJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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