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    AURKAIP1 aurora kinase A interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 54998, updated on 5-Mar-2024

    Summary

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    Official Symbol
    AURKAIP1provided by HGNC
    Official Full Name
    aurora kinase A interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24114
    See related
    Ensembl:ENSG00000175756 MIM:609183; AllianceGenome:HGNC:24114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP; AKIP; mS38; MRP-S38
    Summary
    Acts upstream of or within positive regulation of proteolysis. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 40.0), kidney (RPKM 27.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1373736..1375207, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (804285..805756, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1309116..1310587, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1 Neighboring gene microRNA 6808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1281421-1282299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1282501-1283130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1283131-1283760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 64 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1288877-1289508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1289509-1290140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1290141-1290771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1291896-1292448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1293036-1293618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 65 Neighboring gene matrix remodeling associated 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 66 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1307318-1308085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 67 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1310373-1311278 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1317401-1317943 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 8 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1317944-1318485 Neighboring gene cyclin L2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1328342-1328842 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 69 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein. Huh HC, et al. Nutr Cancer, 2011. PMID 21932983
    2. The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents. Wysong DR, et al. Cell Cycle, 2009 Mar 15. PMID 19221504
    3. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. Katayama H, et al. J Cell Biochem, 2007 Dec 1. PMID 17957726
    4. Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma. Sun T, et al. Carcinogenesis, 2004 Nov. PMID 15271856
    5. AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta. Fumoto K, et al. Oncogene, 2008 Jul 24. PMID 18391981

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer.
      Title: AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer.
    2. Encodes a mitochondrial protein
      Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
    3. Aurora-A protein increased in stomach cancer cells in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin.
      Title: Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    5. Aurora A is necessary for the maintenance of the mitotic delay induced in response to microtubule-perturbing agents.
      Title: The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents.
    6. Plk1 controls Aurora A localization and function by regulating cellular levels of hBora.
      Title: Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.
    7. GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP.
      Title: AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.
    8. AKURA phosphorylation of AIP and stabilization of the enzyme-substrate complex are reported.
      Title: Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.
    9. We propose that AURKAIP1 might function upstream of the Az1 by enhancing the binding affinity of Az1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation.
      Title: Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.
    10. Results describe the identification of a novel negative regulator of Aurora-A, named AIP (Aurora-A kinase Interacting Protein).
      Title: Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20608

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of mitotic nuclear division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS38
    Names
    28S ribosomal protein S38, mitochondrial
    AURKA-interacting protein
    aurora kinase A-interacting protein
    aurora-A kinase interacting protein
    mitochondrial small ribosomal subunit protein mS38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127229.2 → NP_001120701.1  small ribosomal subunit protein mS38

      See identical proteins and their annotated locations for NP_001120701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      AK000615, AL139287, AW576100, BM781908, F31434
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q5TA36, Q8TBD3, Q9NWT8
      Related
      ENSP00000368130.3, ENST00000378853.3
      Conserved Domains (1) summary
      pfam08213
      Location:127 → 157
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    2. NM_001127230.2 → NP_001120702.1  small ribosomal subunit protein mS38

      See identical proteins and their annotated locations for NP_001120702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      AL139287, BC022808, BC062333, BE903314, BP198074, DN994953
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q5TA36, Q8TBD3, Q9NWT8
      Related
      ENSP00000319778.5, ENST00000321751.9
      Conserved Domains (1) summary
      pfam08213
      Location:127 → 157
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    3. NM_017900.3 → NP_060370.1  small ribosomal subunit protein mS38

      See identical proteins and their annotated locations for NP_060370.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      BC062333, BG764236
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q5TA36, Q8TBD3, Q9NWT8
      Related
      ENSP00000340656.5, ENST00000338338.10
      Conserved Domains (1) summary
      pfam08213
      Location:127 → 157
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1373736..1375207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      804285..805756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWT8.1 GenPept UniProtKB/Swiss-Prot:Q9NWT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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