Kntc1 kinetochore associated 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kntc1provided by RGD
Full Name: kinetochore associated 1provided by RGD
Primary source: RGD:1307905
See related: Ensembl:ENSRNOG00000033658 AllianceGenome:RGD:1307905
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore involved in kinetochore assembly. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be part of RZZ complex. Predicted to be active in cytoplasm and kinetochore microtubule. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 82.4), Spleen (RPKM 52.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15-q16

Exon count:: 65

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (38429925..38500564, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32769020..32839617, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38200463..38274162, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore involved in kinetochore assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RZZ complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RZZ complex	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinetochore-associated protein 1

Names: kinetochore-associated protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107140.1 → NP_001100610.1 kinetochore-associated protein 1

See identical proteins and their annotated locations for NP_001100610.1

Status: PROVISIONAL

Source sequence(s)

CH473973

UniProtKB/TrEMBL

A6J131, D3ZVJ3

Related

ENSRNOP00000063431.2, ENSRNOT00000063990.4

Conserved Domains (1) summary

pfam10493
Location:1427 → 1970

Rod_C; Rough deal protein C-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

38429925..38500564 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769228.4 → XP_008767450.1 kinetochore-associated protein 1 isoform X1

See identical proteins and their annotated locations for XP_008767450.1

UniProtKB/TrEMBL

A0A8I6G9X6

Related

ENSRNOP00000084132.1

Conserved Domains (1) summary

pfam10493
Location:1582 → 2125

Rod_C; Rough deal protein C-terminal region
XM_063271315.1 → XP_063127385.1 kinetochore-associated protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6G9X6
XM_039089456.2 → XP_038945384.1 kinetochore-associated protein 1 isoform X2

Conserved Domains (1) summary

pfam10493
Location:1430 → 1974

Rod_C; Rough deal protein C-terminal region