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    Trappc6a trafficking protein particle complex 6A [ Mus musculus (house mouse) ]

    Gene ID: 67091, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trappc6aprovided by MGI
    Official Full Name
    trafficking protein particle complex 6Aprovided by MGI
    Primary source
    MGI:MGI:1914341
    See related
    Ensembl:ENSMUSG00000002043 AllianceGenome:MGI:1914341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mhyp; TRS33; 1810073E21Rik; 4930519D19Rik
    Summary
    Acts upstream of or within melanosome assembly. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of TRAPP complex. Predicted to be active in cis-Golgi network and trans-Golgi network. Orthologous to human TRAPPC6A (trafficking protein particle complex subunit 6A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 87.4), colon adult (RPKM 73.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trappc6a in Genome Data Viewer
    Location:
    7 A3; 7 9.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19242595..19250070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19508665..19516145)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 3-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E6520 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 3 Neighboring gene NTPase, KAP family P-loop domain containing 1 Neighboring gene protein phosphatase 1, regulatory subunit 37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Chang JY, et al. Oncotarget, 2015 Feb 28. PMID 25650666, Free PMC Article
    2. Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Matthews RJ, et al. Proc Natl Acad Sci U S A, 1990 Jun. PMID 2162042, Free PMC Article
    3. A mouse TRAPP-related protein is involved in pigmentation. Gwynn B, et al. Genomics, 2006 Aug. PMID 16697553
    4. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117907

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in COPII vesicle coating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle tethering NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPPIII protein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 6A
    Names
    TRAPP complex subunit 6A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331181.1 → NP_001318110.1  trafficking protein particle complex subunit 6A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a longer, distinct C-terminus than isoform 1.
      Source sequence(s)
      AC149052
      Consensus CDS
      CCDS90174.1
      UniProtKB/Swiss-Prot
      Q78XR0
      Related
      ENSMUSP00000104095.2, ENSMUST00000108455.8

    2. NM_025960.4 → NP_080236.2  trafficking protein particle complex subunit 6A isoform a

      See identical proteins and their annotated locations for NP_080236.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AC149052, AK007965
      Consensus CDS
      CCDS20905.1
      UniProtKB/Swiss-Prot
      Q3KQP0, Q78XR0, Q8C2C8, Q9CQ27, Q9D8H6
      Related
      ENSMUSP00000002112.9, ENSMUST00000002112.15
      Conserved Domains (1) summary
      cd14944
      Location:3 → 157
      TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex

    RNA

    1. NR_138582.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149052
      Related
      ENSMUST00000147114.2

    2. NR_138583.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149052
      Related
      ENSMUST00000136873.8

    3. NR_138584.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149052

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19242595..19250070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242919.2 → XP_030098779.1  trafficking protein particle complex subunit 6A isoform X1

      Conserved Domains (1) summary
      cd14944
      Location:3 → 129
      TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78XR0.1 GenPept UniProtKB/Swiss-Prot:Q78XR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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