Gdi2 GDP dissociation inhibitor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gdi2provided by RGD
Official Full Name: GDP dissociation inhibitor 2provided by RGD
Primary source: RGD:61802
See related: Ensembl:ENSRNOG00000018091 AllianceGenome:RGD:61802
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gdi3
Summary: Enables Rab GDP-dissociation inhibitor activity and small GTPase binding activity. Involved in vesicle-mediated transport. Is active in synapse. Orthologous to human GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1141.8), Spleen (RPKM 1135.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (71559460..71586147, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66649616..66676299, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (70299177..70325864, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127379 (e-PCR)
- UniSTS:210689

RH140864 (e-PCR)
- UniSTS:210689

RH133700 (e-PCR)
- UniSTS:216983

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
contributes_to GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables Rab GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rab GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables Rab GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rab GDP dissociation inhibitor beta

Names: GDI-2; GDI-3; guanosine diphosphate (GDP) dissociation inhibitor 3; guanosine diphosphate dissociation inhibitor 2; guanosine diphosphate dissociation inhibitor 3; rab GDI beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.