Bcap31 B-cell receptor-associated protein 31 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcap31provided by RGD
Official Full Name: B-cell receptor-associated protein 31provided by RGD
Primary source: RGD:1302944
See related: Ensembl:ENSRNOG00000055756 AllianceGenome:RGD:1302944
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bap31
Summary: Predicted to enable MHC class I protein binding activity. Predicted to be involved in several processes, including cellular calcium ion homeostasis; positive regulation of proteolysis; and protein localization to organelle. Predicted to act upstream of or within immune response and spermatogenesis. Located in Golgi cisterna membrane; clathrin-coated vesicle; and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to human BCAP31 (B cell receptor associated protein 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 676.7), Kidney (RPKM 499.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (156548911..156581002, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (151397567..151429666, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (157094365..157126397)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

generated a novel MAb specific for rat BAP31 in immunohistochemistry and localized BAP31 in some rat tissues. Immunoreactivity of BAP31 was prominent in fundic glands, colon, pancreatic acinuses, and liver but not in skeleton muscle and lung
Title: Novel immunohistochemical monoclonal antibody against rat B cell receptor Associated Protein 31 (BAP31).

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128478 (e-PCR)
- UniSTS:211786

BE117505 (e-PCR)
- UniSTS:248694

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune response	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell receptor-associated protein 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004224.1 → NP_001004224.1 B-cell receptor-associated protein 31

See identical proteins and their annotated locations for NP_001004224.1

Status: PROVISIONAL

Source sequence(s)

BC079182

UniProtKB/TrEMBL

A0A0G2JXK2, A0A8I5ZTY8, Q6AY58

Related

ENSRNOP00000070305.2, ENSRNOT00000091792.2

Conserved Domains (2) summary

pfam05529
Location:1 → 136

Bap31; B-cell receptor-associated protein 31-like

pfam18035
Location:192 → 245

Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

156548911..156581002 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229556.5 → XP_006229618.1 B-cell receptor-associated protein 31 isoform X2

See identical proteins and their annotated locations for XP_006229618.1

UniProtKB/TrEMBL

A0A0G2JXK2, A0A8I5ZTY8, Q6AY58

Conserved Domains (2) summary

pfam05529
Location:1 → 136

Bap31; B-cell receptor-associated protein 31-like

pfam18035
Location:192 → 245

Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain
XM_006229557.4 → XP_006229619.1 B-cell receptor-associated protein 31 isoform X2

See identical proteins and their annotated locations for XP_006229619.1

UniProtKB/TrEMBL

A0A0G2JXK2, A0A8I5ZTY8, Q6AY58

Related

ENSRNOP00000082335.1

Conserved Domains (2) summary

pfam05529
Location:1 → 136

Bap31; B-cell receptor-associated protein 31-like

pfam18035
Location:192 → 245

Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain
XM_063279836.1 → XP_063135906.1 B-cell receptor-associated protein 31 isoform X1
XM_039099529.2 → XP_038955457.1 B-cell receptor-associated protein 31 isoform X2

UniProtKB/TrEMBL

A0A0G2JXK2, A0A8I5ZTY8, Q6AY58

Related

ENSRNOP00000083599.1

Conserved Domains (2) summary

pfam05529
Location:1 → 136

Bap31; B-cell receptor-associated protein 31-like

pfam18035
Location:192 → 245

Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain