Cd48 Cd48 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd48provided by RGD
Official Full Name: Cd48 moleculeprovided by RGD
Primary source: RGD:620620
See related: Ensembl:ENSRNOG00000004737 AllianceGenome:RGD:620620
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SLAMF2
Summary: Predicted to enable antigen binding activity and signaling receptor activity. Involved in mast cell activation. Located in plasma membrane. Is anchored component of plasma membrane. Part of protein-containing complex. Orthologous to human CD48 (CD48 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 790.6), Spleen (RPKM 675.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86717960..86741540)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84184884..84209144)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (90116601..90140371)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD48 is a CD2 and CD244 (2B4)-binding protein
Title: Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.
CD48 has been identified as a critical mediator of mast cell activation following exposure to Mycobacterium tuberculosis.
Title: Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	ISO Inferred from Sequence Orthology more info
involved_in mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CD48 antigen

Names: BCM1 surface antigen; BLAST-1; MRC OX-45 surface antigen; SLAM family member 2; signaling lymphocytic activation molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139103.1 → NP_620803.1 CD48 antigen precursor

See identical proteins and their annotated locations for NP_620803.1

Status: PROVISIONAL

Source sequence(s)

X13016

UniProtKB/Swiss-Prot

P10252

UniProtKB/TrEMBL

A0A8I5ZNL0, A6JG07

Related

ENSRNOP00000006306.5, ENSRNOT00000006306.8

Conserved Domains (3) summary

cd05741
Location:36 → 124

Ig_CEACAM_D1_like; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins

smart00410
Location:29 → 107

IG_like; Immunoglobulin like

pfam13895
Location:140 → 202

Ig_2; Immunoglobulin domain