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    Akap17a A-kinase anchoring protein 17A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288526, updated on 2-May-2024

    Summary

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    Official Symbol
    Akap17aprovided by RGD
    Official Full Name
    A-kinase anchoring protein 17Aprovided by RGD
    Primary source
    RGD:1564640
    See related
    Ensembl:ENSRNOG00000028211 AllianceGenome:RGD:1564640
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be active in cytosol and nuclear speck. Orthologous to human AKAP17A (A-kinase anchoring protein 17A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 73.3), Spleen (RPKM 56.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21424202..21428308, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16310427..16315166, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (18527116..18531780, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase X-linked Neighboring gene acetylserotonin O-methyltransferase Neighboring gene acetylserotonin O-methyltransferase-like Neighboring gene interleukin 3 receptor subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments. Jarnaess E, et al. J Biol Chem, 2009 Dec 11. PMID 19840947, Free PMC Article
    2. XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. Mangs AH, et al. Nucleic Acids Res, 2006. PMID 16982639, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 17A
    Names
    A kinase (PRKA) anchor protein 17A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127246.2 → NP_001120718.2  A-kinase anchor protein 17A

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      B2RYB9, F1MAF2
      Related
      ENSRNOP00000032594.4, ENSRNOT00000037829.5
      Conserved Domains (2) summary
      pfam15709
      Location:282 → 445
      DUF4670; Domain of unknown function (DUF4670)
      cl17169
      Location:147 → 278
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      21424202..21428308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248999.4 → XP_006249061.1  A-kinase anchor protein 17A isoform X1

      See identical proteins and their annotated locations for XP_006249061.1

      UniProtKB/TrEMBL
      B2RYB9, F1MAF2
      Conserved Domains (2) summary
      pfam15709
      Location:282 → 445
      DUF4670; Domain of unknown function (DUF4670)
      cl17169
      Location:147 → 278
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_006249000.4 → XP_006249062.1  A-kinase anchor protein 17A isoform X1

      See identical proteins and their annotated locations for XP_006249062.1

      UniProtKB/TrEMBL
      B2RYB9, F1MAF2
      Conserved Domains (2) summary
      pfam15709
      Location:282 → 445
      DUF4670; Domain of unknown function (DUF4670)
      cl17169
      Location:147 → 278
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_006248998.4 → XP_006249060.1  A-kinase anchor protein 17A isoform X1

      See identical proteins and their annotated locations for XP_006249060.1

      UniProtKB/TrEMBL
      B2RYB9, F1MAF2
      Conserved Domains (2) summary
      pfam15709
      Location:282 → 445
      DUF4670; Domain of unknown function (DUF4670)
      cl17169
      Location:147 → 278
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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