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    Nhlrc3 NHL repeat containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310416, updated on 3-Apr-2024

    Summary

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    Symbol
    Nhlrc3provided by RGD
    Full Name
    NHL repeat containing 3provided by RGD
    Primary source
    RGD:1565414
    See related
    Ensembl:ENSRNOG00000070230 AllianceGenome:RGD:1565414
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565414
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Orthologous to human NHLRC3 (NHL repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 172.1), Thymus (RPKM 108.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nhlrc3 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (139678127..139692423, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (137527843..137542258, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (142672188..142686593, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485911 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene NHP2 ribonucleoprotein, pseudogene 1 Neighboring gene proline and serine rich 1 Neighboring gene stomatin like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NHL repeat-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      139678127..139692423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761017.4 → XP_008759239.3  NHL repeat-containing protein 3 isoform X1

    2. XM_017591256.3 → XP_017446745.1  NHL repeat-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKD4
      Conserved Domains (2) summary
      cd05819
      Location:107 → 153
      NHL; NHL repeat [structural motif]
      cl18310
      Location:66 → 336
      NHL; NHL repeat unit of beta-propeller proteins

    3. XM_063282891.1 → XP_063138961.1  NHL repeat-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A6JV96

    4. XM_039103680.2 → XP_038959608.1  NHL repeat-containing protein 3 isoform X4

      Conserved Domains (2) summary
      cd05819
      Location:57 → 96
      NHL; NHL repeat [structural motif]
      cl18310
      Location:12 → 227
      NHL; NHL repeat unit of beta-propeller proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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