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    Prss23 serine protease 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308807, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Prss23provided by RGD
    Official Full Name
    serine protease 23provided by RGD
    Primary source
    RGD:1359545
    See related
    Ensembl:ENSRNOG00000017307 AllianceGenome:RGD:1359545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in nucleus. Orthologous to human PRSS23 (serine protease 23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 564.2), Kidney (RPKM 390.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prss23 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (152815301..152835005, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (143402725..143422182, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (153732528..153742111, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 4 Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 2 Neighboring gene uncharacterized LOC103691188 Neighboring gene uncharacterized LOC102549783 Neighboring gene malic enzyme 3 Neighboring gene uncharacterized LOC120099878

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94216

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine protease 23
    Names
    protease, serine, 23
    NP_001007692.1
    XP_017444659.1
    XP_038969012.1
    XP_038969013.1
    XP_038969017.1
    XP_038969020.1
    XP_063118806.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007691.1 → NP_001007692.1  serine protease 23 precursor

      See identical proteins and their annotated locations for NP_001007692.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079179
      UniProtKB/Swiss-Prot
      Q6AY61
      UniProtKB/TrEMBL
      A0A8I6ALA9, A6I603
      Related
      ENSRNOP00000084133.1, ENSRNOT00000095166.1
      Conserved Domains (1) summary
      cl21584
      Location:147 → 255
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      152815301..152835005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262736.1 → XP_063118806.1  serine protease 23 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALA9, A0A8L2QCB8

    2. XM_017589170.3 → XP_017444659.1  serine protease 23 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALA9, A0A8L2QCB8
      Related
      ENSRNOP00000023239.4
      Conserved Domains (1) summary
      cl21584
      Location:156 → 264
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. XM_039113085.2 → XP_038969013.1  serine protease 23 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALA9
      Conserved Domains (1) summary
      cl21584
      Location:155 → 263
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. XM_039113089.2 → XP_038969017.1  serine protease 23 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALA9
      Related
      ENSRNOP00000089563.1
      Conserved Domains (1) summary
      cl21584
      Location:155 → 263
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    5. XM_039113084.2 → XP_038969012.1  serine protease 23 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALA9, A0A8L2QCB8
      Conserved Domains (1) summary
      cl21584
      Location:156 → 264
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    6. XM_039113092.2 → XP_038969020.1  serine protease 23 isoform X3

      UniProtKB/Swiss-Prot
      Q6AY61
      UniProtKB/TrEMBL
      A0A8I6ALA9, A6I603
      Conserved Domains (1) summary
      cl21584
      Location:147 → 255
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY61.1 GenPept UniProtKB/Swiss-Prot:Q6AY61

    Gene LinkOut

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