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    Slc22a18 solute carrier family 22, member 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309131, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc22a18provided by RGD
    Official Full Name
    solute carrier family 22, member 18provided by RGD
    Primary source
    RGD:1303323
    See related
    Ensembl:ENSRNOG00000020562 AllianceGenome:RGD:1303323
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter activity and ubiquitin protein ligase binding activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in apical plasma membrane; cytoplasm; and nuclear envelope. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SLC22A18 (solute carrier family 22 member 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 498.5), Kidney (RPKM 422.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208100032..208124382)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198670626..198694977)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216676330..216700632)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily Q member 1 Neighboring gene uncharacterized LOC120099963 Neighboring gene cyclin-dependent kinase inhibitor 1C Neighboring gene pleckstrin homology-like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene small nucleolar RNA, H/ACA box 54

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Roles of Imprinted SLC22A18 and SLC22A18AS Gene Overexpression Caused by Promoter CpG Island Hypomethylation as Diagnostic and Prognostic Biomarkers for Non-Small Cell Lung Cancer Patients. Noguera-Uclés JF, et al. Cancers (Basel), 2020 Jul 27. PMID 32726996, Free PMC Article
    2. A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat. Yamamoto T, et al. Biochem Biophys Res Commun, 2013 Nov 1. PMID 24099777
    3. DNA methylation as an adjunct to histopathology to detect prevalent, inconspicuous dysplasia and early-stage neoplasia in Barrett's esophagus. Alvi MA, et al. Clin Cancer Res, 2013 Feb 15. PMID 23243219, Free PMC Article
    4. Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer. Jung Y, et al. Oncotarget, 2015 Sep 22. PMID 26196590, Free PMC Article
    5. [Expression and its clinical significance of SLC22A18 in non-small cell lung cancer]. Lei M, et al. Zhongguo Fei Ai Za Zhi, 2012 Jan. PMID 22237119, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results reveal a novel link between Slc22a18 and fat accumulation and suggest that this gene could be a new therapeutic target in obesity.
      Title: A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94186

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 18
    Names
    ORCTL-2
    organic cation transporter-like protein 2
    solute carrier family 22 (organic cation transporter), member 18
    tumor suppressing subtransferable candidate 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004260.1 → NP_001004260.1  solute carrier family 22 member 18

      See identical proteins and their annotated locations for NP_001004260.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079159
      UniProtKB/Swiss-Prot
      Q6AY78
      UniProtKB/TrEMBL
      A0A0G2JSS3
      Related
      ENSRNOP00000027925.3, ENSRNOT00000027925.5
      Conserved Domains (2) summary
      cd06174
      Location:18 → 382
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:18 → 369
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      208100032..208124382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230775.5 → XP_006230837.1  solute carrier family 22 member 18 isoform X1

      See identical proteins and their annotated locations for XP_006230837.1

      UniProtKB/Swiss-Prot
      Q6AY78
      UniProtKB/TrEMBL
      A0A0G2JSS3
      Conserved Domains (2) summary
      cd06174
      Location:18 → 382
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:18 → 369
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY78.2 GenPept UniProtKB/Swiss-Prot:Q6AY78

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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