U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Glyctk glycerate kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684314, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Glyctkprovided by RGD
    Official Full Name
    glycerate kinaseprovided by RGD
    Primary source
    RGD:1591498
    See related
    Ensembl:ENSRNOG00000046307 AllianceGenome:RGD:1591498
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glycerate kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in D-glyceric aciduria. Orthologous to human GLYCTK (glycerate kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 488.8), Kidney (RPKM 468.3) and 3 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Glyctk in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115676071..115681403, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106795461..106802675, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (114846210..114853374, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene collagen, type VI, alpha 4 Neighboring gene ribosomal protein L6, pseudogene 10 Neighboring gene microRNA let-7g Neighboring gene WD repeat domain 82 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1M

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2. Guo JH, et al. DNA Seq, 2006 Feb. PMID 16753811
    2. Purification of rat liver glycerate kinase and studies of its enzymatic and immunological properties. Katayama H, et al. J Biochem, 1980 Sep. PMID 6252205
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glycerate kinase
    NP_001102919.1
    XP_006243918.1
    XP_006243919.1
    XP_038938080.1
    XP_038938083.1
    XP_063122211.1
    XP_063122212.1
    XP_063122213.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109449.2 → NP_001102919.1  glycerate kinase

      See identical proteins and their annotated locations for NP_001102919.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105621
      UniProtKB/Swiss-Prot
      Q0VGK3
      UniProtKB/TrEMBL
      A6I2P3
      Related
      ENSRNOP00000064339.1, ENSRNOT00000074595.2
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115676071..115681403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266142.1 → XP_063122212.1  glycerate kinase isoform X2

    2. XM_006243857.5 → XP_006243919.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_006243919.1

      UniProtKB/Swiss-Prot
      Q0VGK3
      UniProtKB/TrEMBL
      A6I2P3
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    3. XM_063266143.1 → XP_063122213.1  glycerate kinase isoform X2

    4. XM_039082152.2 → XP_038938080.1  glycerate kinase isoform X1

      UniProtKB/Swiss-Prot
      Q0VGK3
      UniProtKB/TrEMBL
      A6I2P3
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    5. XM_006243856.5 → XP_006243918.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_006243918.1

      UniProtKB/Swiss-Prot
      Q0VGK3
      UniProtKB/TrEMBL
      A6I2P3
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    6. XM_063266141.1 → XP_063122211.1  glycerate kinase isoform X2

    7. XM_039082155.2 → XP_038938083.1  glycerate kinase isoform X3

      Conserved Domains (1) summary
      COG2379
      Location:4 → 388
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VGK3.1 GenPept UniProtKB/Swiss-Prot:Q0VGK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous