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    Xpr1 xenotropic and polytropic retrovirus receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289424, updated on 2-May-2024

    Summary

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    Symbol
    Xpr1provided by RGD
    Full Name
    xenotropic and polytropic retrovirus receptor 1provided by RGD
    Primary source
    RGD:1306554
    See related
    Ensembl:ENSRNOG00000000042 AllianceGenome:RGD:1306554
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SLC53A1
    Summary
    Predicted to enable several functions, including inositol hexakisphosphate binding activity; phosphate ion transmembrane transporter activity; and virus receptor activity. Predicted to be involved in cellular phosphate ion homeostasis; cellular response to phosphate starvation; and phosphate ion transmembrane transport. Predicted to act upstream of or within response to virus. Predicted to be intrinsic component of plasma membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 119.5), Brain (RPKM 89.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Xpr1 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (69991517..70136249, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (67441205..67585950, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (72918552..73056785, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene syntaxin 6 Neighboring gene KIAA1614 homolog Neighboring gene uncharacterized LOC102553685 Neighboring gene ribosomal protein S17 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans. Giovannini D, et al. Cell Rep, 2013 Jun 27. PMID 23791524
    2. Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains. Wild R, et al. Science, 2016 May 20. PMID 27080106
    3. Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1. Yang YL, et al. Nat Genet, 1999 Feb. PMID 9988277
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Olsen JV, et al. Sci Signal, 2010 Jan 12. PMID 20068231
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol hexakisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to phosphate starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 53 member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105992.1 → NP_001099462.1  solute carrier family 53 member 1

      See identical proteins and their annotated locations for NP_001099462.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473958
      UniProtKB/TrEMBL
      A0A8I6ABE7, A6ICY8
      Related
      ENSRNOP00000000049.5, ENSRNOT00000000049.7
      Conserved Domains (2) summary
      cd14477
      Location:2 → 165
      SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins
      pfam03124
      Location:268 → 617
      EXS; EXS family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      69991517..70136249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090615.2 → XP_038946543.1  solute carrier family 53 member 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXZ7, A0A8I6GL93
      Related
      ENSRNOP00000095690.1
      Conserved Domains (2) summary
      cd14477
      Location:2 → 143
      SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins
      pfam03124
      Location:246 → 595
      EXS; EXS family
    Nucleotide Protein Strain
    Heading Accession and Version

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