U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ppa2 inorganic pyrophosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310856, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ppa2provided by RGD
    Official Full Name
    inorganic pyrophosphatase 2provided by RGD
    Primary source
    RGD:1307965
    See related
    Ensembl:ENSRNOG00000012091 AllianceGenome:RGD:1307965
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307965
    Summary
    Predicted to enable inorganic diphosphatase activity; magnesium ion binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in diphosphate metabolic process; phosphate-containing compound metabolic process; and regulation of mitochondrial membrane potential. Predicted to be active in cytosol and mitochondrion. Orthologous to human PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 195.7), Heart (RPKM 116.1) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    2q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (224472738..224552101)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221800791..221878079)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (238528978..238606903)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene uncharacterized LOC102546359 Neighboring gene GC-rich promoter binding protein 1-like 2 Neighboring gene tet methylcytosine dioxygenase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Biallelic PPA2 Mutations Cause Sudden Unexpected Cardiac Arrest in Infancy. Guimier A, et al. Am J Hum Genet, 2016 Sep 1. PMID 27523598, Free PMC Article
    2. Sudden Cardiac Death Due to Deficiency of the Mitochondrial Inorganic Pyrophosphatase PPA2. Kennedy H, et al. Am J Hum Genet, 2016 Sep 1. PMID 27523597, Free PMC Article
    3. Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. Xing Y, et al. J Exp Med, 2005 Sep 5. PMID 16129705, Free PMC Article
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in diphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate-containing compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    inorganic pyrophosphatase 2, mitochondrial
    Names
    pyrophosphatase (inorganic) 2
    NP_001129343.1
    XP_006233389.1
    XP_038958390.1
    XP_063138033.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135871.1 → NP_001129343.1  inorganic pyrophosphatase 2, mitochondrial

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HVU8
      Related
      ENSRNOP00000084906.1, ENSRNOT00000109670.1
      Conserved Domains (1) summary
      cl00217
      Location:23 → 284
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      224472738..224552101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233327.5 → XP_006233389.1  inorganic pyrophosphatase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6HVU8, D4A830
      Related
      ENSRNOP00000016195.6
      Conserved Domains (1) summary
      cl00217
      Location:23 → 284
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    2. XM_039102462.2 → XP_038958390.1  inorganic pyrophosphatase 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZ13
      Conserved Domains (1) summary
      cl00217
      Location:1 → 196
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    3. XM_063281963.1 → XP_063138033.1  inorganic pyrophosphatase 2, mitochondrial isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous