Uba6 ubiquitin-like modifier activating enzyme 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uba6provided by RGD
Official Full Name: ubiquitin-like modifier activating enzyme 6provided by RGD
Primary source: RGD:1308324
See related: Ensembl:ENSRNOG00000021931 AllianceGenome:RGD:1308324
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ube1l2; RGD1308324
Summary: Predicted to enable FAT10 activating enzyme activity and ubiquitin activating enzyme activity. Predicted to be involved in cellular response to DNA damage stimulus; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within several processes, including dendritic spine development; learning; and limbic system development. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBA6 (ubiquitin like modifier activating enzyme 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 194.8), Adrenal (RPKM 157.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p21

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (22238832..22302650)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (21884039..21947857)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (23507628..23571446)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down-regulation of UBA6 exacerbates brain injury by inhibiting the activation of Notch signaling pathway to promote cerebral cell apoptosis in rat acute cerebral infarction model.
Title: Down-regulation of UBA6 exacerbates brain injury by inhibiting the activation of Notch signaling pathway to promote cerebral cell apoptosis in rat acute cerebral infarction model.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137881 (e-PCR)
- UniSTS:219968

Uba6 (e-PCR), detects polymorphism
- UniSTS:548032

BB446153 (e-PCR)
- UniSTS:207824

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAT10 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables FAT10 activating enzyme activity	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin activating enzyme activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amygdala development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic spine development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-like modifier-activating enzyme 6

Names: ubiquitin-activating enzyme E1-like 2

NP_001100683.1

EC 6.2.1.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107213.1 → NP_001100683.1 ubiquitin-like modifier-activating enzyme 6

See identical proteins and their annotated locations for NP_001100683.1

Status: PROVISIONAL

Source sequence(s)

CH473981

UniProtKB/TrEMBL

A0A8I6AS92, A6JCR8, D4A8H3

Related

ENSRNOP00000030667.4, ENSRNOT00000037509.6

Conserved Domains (4) summary

cd01490
Location:462 → 1005

Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...

cd01491
Location:43 → 428

Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...

TIGR01408
Location:38 → 1046

Ube1; ubiquitin-activating enzyme E1

pfam16191
Location:298 → 358

E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle