Gata2 GATA binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gata2provided by RGD
Official Full Name: GATA binding protein 2provided by RGD
Primary source: RGD:2664
See related: Ensembl:ENSRNOG00000012347 AllianceGenome:RGD:2664
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including cochlea development; neuron migration; and regulation of vesicle-mediated transport. Located in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 128.3), Uterus (RPKM 75.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (122211501..122225058)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (120654205..120667763)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (120129028..120142490)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The trans-repressive action of GATA2 on Gnrhr promoter activity is likely balanced or even hindered by trans-activating effects of LIM homeodomain proteins.
Title: GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.
GATA2 stimulates transcriptional activity of the luteinizing hormone beta gene promoter
Title: GATA transcription factors regulate LHβ gene expression.
hese findings indicate that Gata2 plays a required role in the transition of postmitotic neuronal precursor cells of the retinorecipient layers of the superior colliculus into mature neurons
Title: Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus.
There may be a regulatory role played by the Gata-3,-2 transcription factors in prestin expression.
Title: Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture.
These results demonstrate that GATA-2 is involved in multiple promoter regions to activate the specific expression of the rPL-I gene in placental tissue.
Title: Identification of trophoblast-specific binding sites for GATA-2 that are essential for rat placental lactogen-I gene expression.
clenbuterol may act through upregulating the GATA-2 transcription factor and implicate certain PKC isoforms in the drug-induced regulation of skeletal muscle development.
Title: Clenbuterol increases muscle fiber size and GATA-2 protein in rat skeletal muscle in utero.
GATA2 has a role in the transcriptional up-regulation of endothelial cell matrix metalloproteinase-2 in response to extracellular cues
Title: Transcriptional up-regulation of endothelial cell matrix metalloproteinase-2 in response to extracellular cues involves GATA-2.
GATA-2 plays an important role in the regulation of phagocytosis in alveolar macrophages during Pneumocystis carinii infection
Title: Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts.
down regulation of GATA-2 gene correlates with reduced phagocytic acitivity of alveolar macrophages in P. carinii infected host
Title: Effect of the transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gata2 (e-PCR), detects polymorphism
- UniSTS:525633

RH139419 (e-PCR)
- UniSTS:221505

BF397922 (e-PCR)
- UniSTS:246386

PMC58532P1 (e-PCR)
- UniSTS:273367

RH140357 (e-PCR)
- UniSTS:222433

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GABAergic neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation in hindbrain	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within definitive hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in eosinophil fate commitment	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glandular epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glandular epithelial cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron maturation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of forebrain neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of primitive erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within semicircular canal development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urogenital system development	ISO Inferred from Sequence Orthology more info
involved_in vascular wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelial transcription factor GATA-2

Names: GATA-bindning protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033442.1 → NP_254277.1 endothelial transcription factor GATA-2

See identical proteins and their annotated locations for NP_254277.1

Status: PROVISIONAL

Source sequence(s)

AY032734

UniProtKB/Swiss-Prot

Q8VHY4, Q924Y4

UniProtKB/TrEMBL

A6IB40, B2DBE1, B2DBE2

Related

ENSRNOP00000017240.1, ENSRNOT00000017240.3

Conserved Domains (1) summary

cd00202
Location:349 → 398

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

122211501..122225058

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107091.2 → XP_038963019.1 endothelial transcription factor GATA-2 isoform X1

UniProtKB/Swiss-Prot

Q8VHY4, Q924Y4

UniProtKB/TrEMBL

A6IB40, B2DBE1, B2DBE2

Conserved Domains (1) summary

cd00202
Location:349 → 398

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017592480.3 → XP_017447969.1 endothelial transcription factor GATA-2 isoform X1

UniProtKB/Swiss-Prot

Q8VHY4, Q924Y4

UniProtKB/TrEMBL

A6IB40, B2DBE1, B2DBE2

Conserved Domains (1) summary

cd00202
Location:349 → 398

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C