Tmem126b transmembrane protein 126B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem126bprovided by RGD
Official Full Name: transmembrane protein 126Bprovided by RGD
Primary source: RGD:1308371
See related: Ensembl:ENSRNOG00000022732 AllianceGenome:RGD:1308371
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308371
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 29. Orthologous to human TMEM126B (transmembrane protein 126B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 200.3), Kidney (RPKM 170.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (153852081..153864038, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (144437142..144451508, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (156262220..156274207)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM126B as a previously overlooked component of the mitochondrial complex I assembly factor (MCIA) complex and show that this protein is indeed required for the formation of respiratory chain complex I.
Title: Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137624 (e-PCR)
- UniSTS:219711

G42651 (e-PCR)
- UniSTS:94551

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to food	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complex I assembly factor TMEM126B, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106280.2 → NP_001099750.2 complex I assembly factor TMEM126B, mitochondrial

See identical proteins and their annotated locations for NP_001099750.2

Status: PROVISIONAL

Source sequence(s)

BC167111

UniProtKB/Swiss-Prot

B2RZD2, G3V8Z8

Related

ENSRNOP00000031739.4, ENSRNOT00000038279.7

Conserved Domains (1) summary

pfam07114
Location:50 → 221

DUF1370; Protein of unknown function (DUF1370)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

153852081..153864038 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105901.2 → XP_038961829.1 complex I assembly factor TMEM126B, mitochondrial isoform X1

UniProtKB/TrEMBL

A6I646

Conserved Domains (1) summary

pfam07114
Location:1 → 135

TMEM126; Transmembrane protein 126