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    Paxx PAXX, non-homologous end joining factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296565, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Paxxprovided by RGD
    Official Full Name
    PAXX, non-homologous end joining factorprovided by RGD
    Primary source
    RGD:1306215
    See related
    AllianceGenome:RGD:1306215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306215
    Summary
    Predicted to enable DNA polymerase binding activity; molecular adaptor activity; and protein homodimerization activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to be located in nucleoplasm. Predicted to be part of nonhomologous end joining complex. Predicted to be active in nucleus and site of double-strand break. Orthologous to human PAXX (PAXX non-homologous end joining factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 138.9), Thymus (RPKM 132.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Paxx in Genome Data Viewer
    Location:
    3p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28672906..28676252, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8274762..8276322, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2678987..2681668, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 2 Neighboring gene chloride intracellular channel 3 Neighboring gene prostaglandin D2 synthase Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Xing M, et al. Nat Commun, 2015 Feb 11. PMID 25670504, Free PMC Article
    2. Alteration of gene expression in rat mammary tumors induced by N-methyl-N-nitrosourea. Young LH, et al. Mol Carcinog, 1996 Apr. PMID 8634083
    3. DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Ochi T, et al. Science, 2015 Jan 9. PMID 25574025, Free PMC Article
    4. XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair. Craxton A, et al. Cell Death Differ, 2015 Jun. PMID 25941166, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nonhomologous end joining complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nonhomologous end joining complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein PAXX
    Names
    uncharacterized protein C9orf142 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399307.1 → NP_001386236.1  protein PAXX isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JT64
      Conserved Domains (1) summary
      pfam15384
      Location:10 → 205
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142

    2. NM_001399308.1 → NP_001386237.1  protein PAXX isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Conserved Domains (1) summary
      pfam15384
      Location:10 → 203
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142

    3. NM_001399309.1 → NP_001386238.1  protein PAXX isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      B2RYB2, G3V7Z0
      Conserved Domains (1) summary
      pfam15384
      Location:1 → 108
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28672906..28676252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104717.2 → XP_038960645.1  protein PAXX isoform X1

      UniProtKB/TrEMBL
      B2RYB2, G3V7Z0
      Conserved Domains (1) summary
      pfam15384
      Location:1 → 108
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106556.2: Suppressed sequence

      Description
      NM_001106556.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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