Cox14 cytochrome c oxidase assembly factor COX14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cox14provided by RGD
Official Full Name: cytochrome c oxidase assembly factor COX14provided by RGD
Primary source: RGD:1598052
See related: AllianceGenome:RGD:1598052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C12orf62
Summary: Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX14 (cytochrome c oxidase assembly factor COX14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 480.8), Heart (RPKM 434.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132731069..132733159)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130852226..130854316)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (141378537..141380960)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Gpd1 (e-PCR), detects polymorphism
- UniSTS:527364

RH127899 (e-PCR)
- UniSTS:211209

AI008150 (e-PCR)
- UniSTS:261429

RH127433 (e-PCR)
- UniSTS:210743

AW061147 (e-PCR)
- UniSTS:178508

22.MMHAP28FLH1.seq (e-PCR)
- UniSTS:123565

RH128342 (e-PCR)
- UniSTS:211650

RH143139 (e-PCR)
- UniSTS:232386

RH124655 (e-PCR)
- UniSTS:161477

BF399697 (e-PCR)
- UniSTS:247763

AA875621 (e-PCR)
- UniSTS:261339

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial cytochrome c oxidase assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome c oxidase assembly protein COX14

Names: COX14 cytochrome c oxidase assembly; COX14, cytochrome c oxidase assembly factor; cytochrome c oxidase assembly protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377081.1 → NP_001364010.1 cytochrome c oxidase assembly protein COX14

Status: VALIDATED

Source sequence(s)

BC084716

UniProtKB/Swiss-Prot

Q5XFV8

Conserved Domains (1) summary

pfam14880
Location:1 → 52

COX14; Cytochrome oxidase c assembly