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    Cwc27 CWC27 spliceosome associated cyclophilin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361887, updated on 2-May-2024

    Summary

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    Official Symbol
    Cwc27provided by RGD
    Official Full Name
    CWC27 spliceosome associated cyclophilinprovided by RGD
    Primary source
    RGD:1310697
    See related
    Ensembl:ENSRNOG00000013252 AllianceGenome:RGD:1310697
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sdccag10
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome and catalytic step 2 spliceosome. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 91.1), Kidney (RPKM 86.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cwc27 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (37498462..37709691, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (35764674..35975908, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (34716420..34923060, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 6 Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene ribosomal protein S29, pseudogene 14 Neighboring gene SREK1-interacting protein 1 Neighboring gene shisa like 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. Davis TL, et al. PLoS Biol, 2010 Jul 27. PMID 20676357, Free PMC Article
    2. Structure of the human activated spliceosome in three conformational states. Zhang X, et al. Cell Res, 2018 Mar. PMID 29360106, Free PMC Article
    3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spliceosome-associated protein CWC27 homolog
    Names
    CWC27 spliceosome-associated protein homolog
    PPIase CWC27
    PPIase SDCCAG10
    peptidyl-prolyl cis-trans isomerase CWC27 homolog
    peptidyl-prolyl cis-trans isomerase SDCCAG10
    probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog
    serologically defined colon cancer antigen 10
    NP_001013217.1
    XP_017446439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013199.1 → NP_001013217.1  spliceosome-associated protein CWC27 homolog

      See identical proteins and their annotated locations for NP_001013217.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083774
      UniProtKB/Swiss-Prot
      Q5XIB2
      UniProtKB/TrEMBL
      A0A8L2Q9Q6
      Related
      ENSRNOP00000017832.6, ENSRNOT00000017832.8
      Conserved Domains (2) summary
      cd01925
      Location:8 → 177
      cyclophilin_CeCYP16-like; cyclophilin_CeCYP16-like: cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced ...
      pfam15724
      Location:305 → 356
      TMEM119; TMEM119 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      37498462..37709691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590950.3 → XP_017446439.1  spliceosome-associated protein CWC27 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q9Q6, A6I5G2
      Related
      ENSRNOP00000070377.2
      Conserved Domains (2) summary
      cd01925
      Location:8 → 177
      cyclophilin_CeCYP16-like; cyclophilin_CeCYP16-like: cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced ...
      pfam15724
      Location:308 → 359
      TMEM119; TMEM119 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIB2.1 GenPept UniProtKB/Swiss-Prot:Q5XIB2

    Gene LinkOut

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