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    Tfcp2 transcription factor CP2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315309, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tfcp2provided by RGD
    Official Full Name
    transcription factor CP2provided by RGD
    Primary source
    RGD:1306738
    See related
    Ensembl:ENSRNOG00000032395 AllianceGenome:RGD:1306738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tcfcp2
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein C-terminus binding activity. Predicted to be involved in mRNA transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human TFCP2 (transcription factor CP2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 96.7), Adrenal (RPKM 92.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tfcp2 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133495577..133537799, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131616777..131658995, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142138836..142181036, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 member 2 Neighboring gene uncharacterized LOC120093735 Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2 Neighboring gene uncharacterized LOC120093736 Neighboring gene POU class 6 homeobox 1 Neighboring gene uncharacterized LOC134479579

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcription factor CP2 is involved in activating mBMP4 in mouse mesenchymal stem cells. Kang HC, et al. Mol Cells, 2004 Jun 30. PMID 15232220
    2. Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4. Zhou W, et al. Mol Cell Biol, 2000 Oct. PMID 11003662, Free PMC Article
    3. The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1. Zambrano N, et al. J Biol Chem, 1998 Aug 7. PMID 9685356
    4. PHB2 interacts with RNF2 and represses CP2c-stimulated transcription. Lee SJ, et al. Mol Cell Biochem, 2008 Dec. PMID 18629613
    5. Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Zhao Q, et al. Blood, 2006 Mar 1. PMID 16263792, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187831

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-globin transcription factor CP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134714.2 → NP_001128186.1  alpha-globin transcription factor CP2

      See identical proteins and their annotated locations for NP_001128186.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AB07, B4F788, G3V969
      Related
      ENSRNOP00000037251.5, ENSRNOT00000037447.7
      Conserved Domains (2) summary
      cd09589
      Location:329 → 395
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:52 → 259
      CP2; CP2 transcription factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133495577..133537799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242341.5 → XP_006242403.1  alpha-globin transcription factor CP2 isoform X1

      See identical proteins and their annotated locations for XP_006242403.1

      UniProtKB/TrEMBL
      A0A0G2JTJ9, A0A8I6AB07, A6KCK2
      Related
      ENSRNOP00000068740.1
      Conserved Domains (2) summary
      cd09589
      Location:329 → 395
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:52 → 259
      CP2; CP2 transcription factor

    2. XM_017594896.3 → XP_017450385.1  alpha-globin transcription factor CP2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AB07, B4F788, G3V969
      Conserved Domains (2) summary
      cd09589
      Location:329 → 395
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:52 → 259
      CP2; CP2 transcription factor

    3. XM_017594895.3 → XP_017450384.1  alpha-globin transcription factor CP2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTJ9, A0A8I6AB07, A6KCK2
      Related
      ENSRNOP00000091135.1
      Conserved Domains (2) summary
      cd09589
      Location:329 → 395
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:52 → 259
      CP2; CP2 transcription factor

    4. XM_063263676.1 → XP_063119746.1  alpha-globin transcription factor CP2 isoform X3

    RNA

    1. XR_010052986.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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