Steap4 STEAP4 metalloreductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Steap4provided by RGD
Official Full Name: STEAP4 metalloreductaseprovided by RGD
Primary source: RGD:1560331
See related: Ensembl:ENSRNOG00000008602 AllianceGenome:RGD:1560331
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including FAD binding activity; heme binding activity; and oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor. Predicted to be involved in copper ion import; fat cell differentiation; and protein homotrimerization. Predicted to act upstream of or within iron import into cell. Predicted to be located in nucleoplasm. Predicted to be integral component of membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP4 (STEAP4 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 207.0), Muscle (RPKM 147.4) and 8 other tissues See more
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Genomic context

Location:: 4q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (27032096..27054769, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (26077182..26099859, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (23112682..23135354, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpressing STAMP2 attenuates diabetic renal injuries via upregulating autophagy in diabetic rats.
Title: Overexpressing STAMP2 attenuates diabetic renal injuries via upregulating autophagy in diabetic rats.
Data suggest that Steap4 utilizes an interdomain flavin-binding site to shuttle electrons between the oxidoreductase and transmembrane domains.
Title: The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127944 (e-PCR)
- UniSTS:211254

AU026622 (e-PCR)
- UniSTS:114100

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables cupric reductase (NADH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables cupric reductase (NADH) activity	ISO Inferred from Sequence Orthology more info
enables electron transfer activity	ISO Inferred from Sequence Orthology more info
enables ferric-chelate reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within copper ion import	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metalloreductase STEAP4

Names: Ab1-219; STEAP family member 4; six-transmembrane epithelial antigen of prostate 4

NP_001037730.1

EC 1.16.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044265.1 → NP_001037730.1 metalloreductase STEAP4

See identical proteins and their annotated locations for NP_001037730.1

Status: PROVISIONAL

Source sequence(s)

BC097353

UniProtKB/Swiss-Prot

Q4V8K1

UniProtKB/TrEMBL

A0A8I5Y5X8, A6K246

Related

ENSRNOP00000011432.4, ENSRNOT00000011432.7

Conserved Domains (3) summary

COG2085
Location:24 → 201

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:251 → 318

Ferric_reduct; Ferric reductase like transmembrane component

cl21454
Location:26 → 190

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins