Olig1 oligodendrocyte transcription factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Olig1provided by RGD
Official Full Name: oligodendrocyte transcription factor 1provided by RGD
Primary source: RGD:621129
See related: Ensembl:ENSRNOG00000028648 AllianceGenome:RGD:621129
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Olg1; oligo1
Summary: This gene is a member of the oligodendrocyte lineage gene family which encode basic helix-loop-helix transcription factors. Studies in mice show that it is coexpressed with Olig2 in neural progenitors, and has a role in the development and maturation of oligodendrocytes. [provided by RefSeq, Jul 2008]
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (44000450..44002592)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (30514379..30516521)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (31428377..31430519)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data of the present study may help clinicians understand the expression pattern of Olig1 and its potential role in endogenous remyelination after ischemia, which may have implications for the treatment of diseases that lead to demyelination.
Title: Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats.
these data strongly suggest that bone marrow stromal cells (BMSCs) can promote the differentiation of Neural stem cells (NSCs) into oligodendrocytes through mediating Id2 and Olig1/2 expression by blocking the BMP/Smad signaling pathway
Title: BMSCs promote the differentiation of NSCs into oligodendrocytes via mediating Id2 and Olig expression through BMP/Smad signaling pathway.
Olig1 and Olig2 expression are enhanced during antipsychotic drug induced differentiation of oligodendrocyte progenitor cells.
Title: Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2.
Bimolecular fluorescence complementation (BiFC) analysis was performed to further characterize the distinct subcellular localization of olig1, ID4 and their dimer.
Title: Olig1 and ID4 interactions in living cells visualized by bimolecular fluorescence complementation technique.
Overexpression of olig1 and olig2 inhibits astrocyte differentiation and promotes oligodendrocyte differentiation of adult oligodendrocyte precursor cells.
Title: Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells.

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General gene information

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Markers

AI836478 (e-PCR)
- UniSTS:164612

Olig1 (e-PCR), detects polymorphism
- UniSTS:259640

ECD24242 (e-PCR)
- UniSTS:305226

RH139467 (e-PCR)
- UniSTS:221553

AW523365 (e-PCR)
- UniSTS:243967

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oligodendrocyte transcription factor 1

Names: Olg-1 bHLH protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021770.4 → NP_068538.2 oligodendrocyte transcription factor 1

See identical proteins and their annotated locations for NP_068538.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q9WUQ3

UniProtKB/TrEMBL

A0A0H2UHA2, A6JLE8

Related

ENSRNOP00000002827.6, ENSRNOT00000002827.8

Conserved Domains (1) summary

cd18942
Location:96 → 165

bHLH_TS_OLIG1; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 1 (Oligo1) and similar proteins