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    Wfdc3 WAP four-disulfide core domain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296366, updated on 5-Mar-2024

    Summary

    Official Symbol
    Wfdc3provided by RGD
    Official Full Name
    WAP four-disulfide core domain 3provided by RGD
    Primary source
    RGD:1305295
    See related
    Ensembl:ENSRNOG00000042162 AllianceGenome:RGD:1305295
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be active in extracellular space. Orthologous to human WFDC3 (WAP four-disulfide core domain 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 24.4), Kidney (RPKM 20.4) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Wfdc3 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173884206..173898294, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153464862..153478952, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161193904..161212063, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kunitz type 5 Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 1 Neighboring gene ubiquitin-conjugating enzyme E2C

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    WAP four-disulfide core domain protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106541.1NP_001100011.1  WAP four-disulfide core domain protein 3 precursor

      See identical proteins and their annotated locations for NP_001100011.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474005
      UniProtKB/TrEMBL
      A6JXA8, D4A5P8
      Related
      ENSRNOP00000061678.1, ENSRNOT00000065751.3
      Conserved Domains (1) summary
      pfam00095
      Location:3064
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173884206..173898294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)