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    Glmn glomulin, FKBP associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289437, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Glmnprovided by RGD
    Official Full Name
    glomulin, FKBP associated proteinprovided by RGD
    Primary source
    RGD:1588600
    See related
    Ensembl:ENSRNOG00000002054 AllianceGenome:RGD:1588600
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hepatocyte growth factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase inhibitor activity. Predicted to be involved in several processes, including negative regulation of T cell proliferation; regulation of gene expression; and vasculogenesis. Predicted to act upstream of or within several processes, including neural tube closure; positive regulation of interleukin-2 production; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; and Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in arteriovenous malformation and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 72.0), Thymus (RPKM 57.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Glmn in Genome Data Viewer
    Location:
    14p22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (2332052..2375366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (2187144..2231295)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (3204390..3247703)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ecotropic viral integration site 5 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene growth factor independent 1 transcriptional repressor Neighboring gene RNA polymerase II associated protein 2 Neighboring gene similar to human chromosome 1 open reading frame 146 Neighboring gene uncharacterized LOC108352691 Neighboring gene BTB domain containing 8 Neighboring gene lysophosphatidylcholine acyltransferase 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas"). Brouillard P, et al. Am J Hum Genet, 2002 Apr. PMID 11845407, Free PMC Article
    2. Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor. Grisendi S, et al. J Biol Chem, 2001 Dec 7. PMID 11571281
    3. FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. Chambraud B, et al. J Biol Chem, 1996 Dec 20. PMID 8955134
    4. The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis. Krummrei U, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12604780, Free PMC Article
    5. The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Tron AE, et al. Mol Cell, 2012 Apr 13. PMID 22405651, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hepatocyte growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circulatory system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glomulin
    Names
    FKBP associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105993.1 → NP_001099463.1  glomulin

      See identical proteins and their annotated locations for NP_001099463.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474079
      UniProtKB/TrEMBL
      A0A0G2K255, A6KPI8, D3ZKQ3
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 524
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      2332052..2375366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769922.4 → XP_008768144.1  glomulin isoform X1

      See identical proteins and their annotated locations for XP_008768144.1

      UniProtKB/TrEMBL
      A0A0G2K255, A6KPI8, D3ZKQ3
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 524
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    2. XM_008769924.4 → XP_008768146.2  glomulin isoform X2

    3. XM_063272890.1 → XP_063128960.1  glomulin isoform X3

    4. XM_008769923.4 → XP_008768145.1  glomulin isoform X1

      See identical proteins and their annotated locations for XP_008768145.1

      UniProtKB/TrEMBL
      A0A0G2K255, A6KPI8, D3ZKQ3
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 524
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    5. XM_039091653.2 → XP_038947581.1  glomulin isoform X1

      UniProtKB/TrEMBL
      A0A0G2K255, A6KPI8, D3ZKQ3
      Related
      ENSRNOP00000058301.1
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 524
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    6. XM_039091657.2 → XP_038947585.1  glomulin isoform X4

      Conserved Domains (1) summary
      pfam08568
      Location:14 → 221
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    RNA

    1. XR_005492903.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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