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    Rnf144a ring finger protein 144A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500636, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rnf144aprovided by RGD
    Official Full Name
    ring finger protein 144Aprovided by RGD
    Primary source
    RGD:1561737
    See related
    Ensembl:ENSRNOG00000007370 AllianceGenome:RGD:1561737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf144; RGD1561737
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ubiquitin ligase complex. Predicted to be active in Golgi apparatus. Orthologous to human RNF144A (ring finger protein 144A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 99.0), Heart (RPKM 66.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf144a in Genome Data Viewer
    Location:
    6q16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (48628241..48748241, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (42899767..43019769, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (45509895..45629233, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093243 Neighboring gene phosphoglycerate dehydrogenase, pseudogene 6 Neighboring gene uncharacterized LOC134479352 Neighboring gene radical S-adenosyl methionine domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Ho SR, et al. Proc Natl Acad Sci U S A, 2014 Jul 1. PMID 24979766, Free PMC Article
    2. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pattern recognition receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF144A
    Names
    probable E3 ubiquitin-protein ligase RNF144A
    ring finger protein 144
    NP_001075879.1
    XP_038968637.1
    XP_038968638.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082410.1 → NP_001075879.1  E3 ubiquitin-protein ligase RNF144A

      See identical proteins and their annotated locations for NP_001075879.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFP4, A6HAZ8, D3ZYY5
      Related
      ENSRNOP00000009877.4, ENSRNOT00000009877.7
      Conserved Domains (3) summary
      smart00647
      Location:91 → 156
      IBR; In Between Ring fingers
      cd16777
      Location:19 → 72
      mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
      pfam01485
      Location:179 → 216
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      48628241..48748241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112710.2 → XP_038968638.1  E3 ubiquitin-protein ligase RNF144A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNS4, A0A8I6AFP4
      Related
      ENSRNOP00000079847.1
      Conserved Domains (3) summary
      smart00647
      Location:71 → 136
      IBR; In Between Ring fingers
      pfam01485
      Location:159 → 196
      IBR; IBR domain, a half RING-finger domain
      cl17238
      Location:26 → 52
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_039112709.2 → XP_038968637.1  E3 ubiquitin-protein ligase RNF144A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AFP4, A6HAZ8, D3ZYY5
      Conserved Domains (3) summary
      smart00647
      Location:91 → 156
      IBR; In Between Ring fingers
      cd16777
      Location:19 → 72
      mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
      pfam01485
      Location:179 → 216
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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