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    Tsc22d1 TSC22 domain family, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498545, updated on 6-Jun-2024

    Summary

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    Symbol
    Tsc22d1provided by RGD
    Full Name
    TSC22 domain family, member 1provided by RGD
    Primary source
    RGD:3850
    See related
    Ensembl:ENSRNOG00000001030 AllianceGenome:RGD:3850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TS22A; TSC-22; Tgfb1i4
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human TSC22D1 (TSC22 domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 402.0), Lung (RPKM 370.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tsc22d1 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (58159612..58260244)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (51750489..51850958)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (58554358..58658156)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482155 Neighboring gene uncharacterized LOC120097109 Neighboring gene ribosomal protein S29, pseudogene 6 Neighboring gene uncharacterized LOC120097112 Neighboring gene uncharacterized LOC120097114 Neighboring gene stress-associated endoplasmic reticulum protein family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. Huser CA, et al. Cell Death Differ, 2010 Feb. PMID 19745830
    2. Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. Ohta S, et al. Eur J Biochem, 1996 Dec 15. PMID 9022669
    3. Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression. Hamil KG, et al. Endocrinology, 1994 Mar. PMID 8161377
    4. TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. Yan X, et al. Mol Cell Biol, 2011 Sep. PMID 21791611, Free PMC Article
    5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSC-22 can promote the differentiation of cardiac myofibroblasts by increasing expression of the fibrotic genes for alpha-smooth muscle actin, PAI-1, fibronectin, and collagen I.
      Title: TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156831

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hematopoietic stem cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of programmed cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of programmed cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TSC22 domain family protein 1
    Names
    TGFB-stimulated clone 22 homolog
    Transforming growth factor beta stimulated clone 22
    regulatory protein TSC-22
    transforming growth factor beta 1 induced transcript 4
    transforming growth factor beta-1-induced transcript 4 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109912.1 → NP_001103382.1  TSC22 domain family protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001103382.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      A0JPR0, D3Z8M8, P62501, Q00992
      UniProtKB/TrEMBL
      A0A8I6AF76
      Related
      ENSRNOP00000055007.2, ENSRNOT00000058206.5
      Conserved Domains (1) summary
      pfam01166
      Location:965 → 1011
      TSC22; TSC-22/dip/bun family

    2. NM_013043.2 → NP_037175.1  TSC22 domain family protein 1 isoform 2

      See identical proteins and their annotated locations for NP_037175.1

      Status: VALIDATED

      Source sequence(s)
      BG372788, CB771530, L25785
      UniProtKB/TrEMBL
      A6HTV1
      Related
      ENSRNOP00000001360.2, ENSRNOT00000001360.4
      Conserved Domains (1) summary
      cd21938
      Location:53 → 131
      ZIP_TSC22D1; leucine zipper domain found in TSC22 domain family protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      58159612..58260244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274558.1 → XP_063130628.1  TSC22 domain family protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A0JPR0, D3Z8M8, P62501, Q00992
      UniProtKB/TrEMBL
      A0A8I6AF76

    2. XM_063274557.1 → XP_063130627.1  TSC22 domain family protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A0JPR0, D3Z8M8, P62501, Q00992
      UniProtKB/TrEMBL
      A0A8I6AF76

    3. XM_063274559.1 → XP_063130629.1  TSC22 domain family protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A0JPR0, D3Z8M8, P62501, Q00992
      UniProtKB/TrEMBL
      A0A8I6AF76

    4. XM_006252340.5 → XP_006252402.1  TSC22 domain family protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A468, A0A8I6AF76
      Related
      ENSRNOP00000085587.1
      Conserved Domains (1) summary
      PHA03378
      Location:541 → 826
      PHA03378; EBNA-3B; Provisional

    5. XM_039093593.2 → XP_038949521.1  TSC22 domain family protein 1 isoform X3

      Conserved Domains (1) summary
      cl40461
      Location:1 → 74
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    RNA

    1. XR_005493779.2 RNA Sequence

    2. XR_010057848.1 RNA Sequence

    3. XR_360080.5 RNA Sequence

    4. XR_360081.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62501.2 GenPept UniProtKB/Swiss-Prot:P62501

    Gene LinkOut

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