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    IARS2 isoleucyl-tRNA synthetase 2, mitochondrial [ Bos taurus (cattle) ]

    Gene ID: 533057, updated on 5-Mar-2024

    Summary

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    Official Symbol
    IARS2provided by VGNC
    Official Full Name
    isoleucyl-tRNA synthetase 2, mitochondrialprovided by VGNC
    Primary source
    VGNC:VGNC:30019
    See related
    BGD:BT29807; Ensembl:ENSBTAG00000012582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See IARS2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (23586935..23631282)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene glutamyl-prolyl-tRNA synthetase 1 Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene microRNA mir-194-1 Neighboring gene microRNA mir-194b Neighboring gene microRNA mir-215 Neighboring gene RAB3 GTPase activating non-catalytic protein subunit 2 Neighboring gene microRNA mir-664b Neighboring gene transfer RNA glycine (anticodon CCC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IARS mutation causes prenatal death in Japanese Black cattle. Hirano T, et al. Anim Sci J, 2016 Sep. PMID 27229878
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Its mutation causes prenatal death in Japanese Black cattle
      Title: IARS mutation causes prenatal death in Japanese Black cattle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isoleucine--tRNA ligase, mitochondrial
    Names
    isoleucine-tRNA synthetase 2, mitochondrial
    NP_001193724.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206795.1 → NP_001193724.1  isoleucine--tRNA ligase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      BC102830, DT812568, DV887098, DV894430
      UniProtKB/TrEMBL
      G3MWG4
      Related
      ENSBTAP00000053447.3, ENSBTAT00000061457.3
      Conserved Domains (5) summary
      cd07960
      Location:711 → 890
      Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
      PRK05743
      Location:60 → 1011
      ileS; isoleucyl-tRNA synthetase; Reviewed
      pfam06827
      Location:985 → 1006
      zf-FPG_IleRS; Zinc finger found in FPG and IleRS
      pfam13603
      Location:356 → 410
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
      cl00015
      Location:472 → 708
      nt_trans; nucleotidyl transferase superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23586935..23631282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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