U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NAMPT nicotinamide phosphoribosyltransferase [ Bos taurus (cattle) ]

    Gene ID: 520472, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NAMPTprovided by VGNC
    Official Full Name
    nicotinamide phosphoribosyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:31875
    See related
    BGD:BT23755; Ensembl:ENSBTAG00000015509
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PBEF; PBEF1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NAMPT in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (47321227..47361906, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene baculoviral IAP repeat-containing protein 5-like Neighboring gene uncharacterized LOC104972036 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene coiled-coil domain containing 71 like

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. [Novel 35-bp insertion in visfatin gene in Chinese cattle]. Wang M, et al. Mol Biol (Mosk), 2009 Jul-Aug. PMID 19807021
    2. Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway. Yonezawa T, et al. FEBS Lett, 2006 Dec 11. PMID 17123517
    3. Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis. Lau A, et al. Exp Biol Med (Maywood), 2014 Jan. PMID 24186266
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
      Title: Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis.
    2. the presence of 35bp-insertion in visfatin gene may influence the birth weight and bodyweight in 6-month-old cows.
      Title: [Novel 35-bp insertion in visfatin gene in Chinese cattle].
    3. These results indicate that mammary epithelial cells express the visfatin protein and secrete them into the milk.
      Title: Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nicotinamide phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nicotinamide phosphoribosyltransferase
    Names
    pre-B-cell colony enhancing factor 1
    visfatin
    NP_001231070.1
    XP_010802469.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244141.1 → NP_001231070.1  nicotinamide phosphoribosyltransferase

      See identical proteins and their annotated locations for NP_001231070.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151730, CB431562, CB460095, DR113822, EE900191, EE900192, FE004250
      UniProtKB/TrEMBL
      A0A3Q1M241, F1MJ80
      Related
      ENSBTAP00000064059.1, ENSBTAT00000083136.1
      Conserved Domains (1) summary
      cd01569
      Location:12 → 428
      PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      47321227..47361906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010804167.3 → XP_010802469.1  nicotinamide phosphoribosyltransferase isoform X1

      UniProtKB/TrEMBL
      F1MJ80
      Related
      ENSBTAP00000089013.1, ENSBTAT00000123233.1
      Conserved Domains (2) summary
      PRK09198
      Location:10 → 434
      PRK09198; putative nicotinate phosphoribosyltransferase; Provisional
      cl21457
      Location:12 → 381
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.